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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Muscarinic Antagonists for the Treatment of Depression
Published Monday, June 26, 2023Summary The disclosed technology describes the utilization of muscarinic antagonists for the treatment of depression. Muscarinic antagonists are a class of compounds that block muscarinic acetylcholine receptors to ameliorate...
Investigator(s): Andrew Coop, Jack Bergman, Chad Johnson, Brian Kangas, James Woods, Emily Jukiewicz, Gail Winger
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): depression, Muscarinic Antagonists, Mood Regulation
Docket: AC-2019-107
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Hemofiltration device, system and method for a high blood flow extracorporeal circuit
Published Thursday, May 25, 2023Summary The disclosed invention describes a hemofiltration device, system, and method designed for high blood flow extracorporeal circuits. This technology overcomes the limitations of conventional renal replacement therapy (...
Investigator(s): Alison Grazioli, Joseph Rabin, Ronson Madathil, Rashmikant Shah
Categories: Devices, Methods of Treatment
Keyword(s): Hemofiltration, High Blood Flow, Extracorporeal Circuit, Renal Replacement Therapy
Docket: AG-2019-016
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Gallium-salophen Antimicrobial Compounds and Methods of Use Thereof
Published Wednesday, May 24, 2023Summary Pseudomonas aeruginosa (Pa), a WHO priority 1 pathogen, causes life-threatening infections. Multidrug resistant Pa has been classified by the CDC as a “serious...
Investigator(s): Fengtian Xue, Angela Wilks
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): pharmaceuticals, Clinical Medicine, Antimicrobial Compounds
Docket: FX-2020-101
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Prodrugs of anti-cancer and anti-autoimmune diseases therapeutic agents, and methods of making and use thereof
Published Wednesday, May 17, 2023Summary In summary, the invention disclosed by UMB investigators offers a promising new approach to the treatment of cancer and autoimmune diseases by introducing a series of novel prodrugs with improved safety and efficacy...
Investigator(s): Fengtian Xue, Yan Shu, Yong Li
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Prodrug, cancer, Autoimmune, Therapeutic
Docket: FX-2019-033
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Device and Method for Transseptal Puncture
Published Wednesday, May 17, 2023Atrial fibrillation (AF) and mitral valve (MV) disease are two of the most common cardiac conditions. AF affects between 2.7 and 6.1 million American adults each year. MV disease is the most common heart valve lesion, impacting 1.7% of U.S. adults (9.3% of people ≥ 75 years old). Both AF and...
Investigator(s): James Gammie, Rachel Quinn, Chetan Pasrija
Categories: Devices, Surgical devices, Methods of Treatment
Keyword(s): Atrial fibrilation, Mitral valve, catheter, Transseptal puncture
Docket: JG-2017-030
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Wnt Signaling Pathway Inhibitors for Treatments of Disease
Published Wednesday, May 17, 2023Summary UMB inventors have developed compounds that inhibit the Wnt/β-catenin signaling pathway, which is implicated in various diseases, including cancer and metabolic disorders such as type 2 diabetes, obesity,...
Investigator(s): Fengtian Xue, Yan Shu
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): cancer, Metabolic Disease, diabetes
Docket: FX-2015-082
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Compounds for Treating Parasitic Infections
Published Monday, May 15, 2023Summary Researchers at the University of Maryland, Baltimore and the University of Maryland, College Park have synthesized a new class of 1,3-thiazolidine-2,4-dione derivatives that exhibit potent activity against several protozoan parasites,...
Investigator(s): Fengtian Xue, Iqbal Hamza
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Parsitology, infection, Immunology
Docket: FX-2015-021
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LRP1 Antagonists for Treatment and Prevention of Alzheimer’s Disease
Published Thursday, May 26, 2022Alzheimer’s disease (AD) is a neurodegenerative disease characterized by gradual deterioration of the brain cells and loss of multiple cognitive functions. The cognitive decline in AD is closely linked to aggregated forms of tau which form neurofibrillary tangles (“NFT”) that initiate in the entorhinal cortex...
Investigator(s): Dudley Strickland, Molly Migliorini, Brian Hampton, Joana Cooper, Selen Muratoglu Catania, Bradley Hyman, Aurelien Lathuiliere
Categories: Therapeutics, Methods of Treatment
Keyword(s): Alzheimer’s Disease, Therapeutics, LRP1, Tau, Method, CNS
Docket: DS-2020-052
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NEU1-Selective Sialidase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis
Published Thursday, May 12, 2022Idiopathic Pulmonary Fibrosis (IPF) is an unrelenting, uniformly fatal disease in which lung architecture is distorted and replaced by scar tissue, thereby compromising pulmonary function. IPF patients only survive 2 to 3 years after diagnosis. Although numerous host factors have been implicated in IPF pathogenesis, no unified mechanistic...
Investigator(s): Simeon Goldblum; Irina Luzina; Sergei Atamas
Categories: Therapeutics, Methods of Treatment
Keyword(s): Fibrosis, Therapeutics, IPF
Docket: SG-2019-090
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Method to Preserve Post-radiotherapy Ventilation by Mitigating Radiation-Induced Airway Injury
Published Tuesday, September 7, 2021Preserving post-radiotherapy respiratory function is an important consideration in thoracic radiation therapy. A common limitation of current clinical and investigational approaches that attempt to achieve this objective is that they ignore radiation injury to the elements of the bronchial tree, which are critical to the gas exchange...
Investigator(s): Amit Sawant; Esther Vicente; Arezoo Modiri; Robert Timmerman; Yulong Yan; Henky Wibowo
Categories: Imaging, Healthcare, Methods of Treatment
Keyword(s): Radiation Treatment Planning; Software; Imaging; Oncology; Cancer
Docket: AS-2019-095