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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Novel multidrug resistance transporter isolated from human breast cancer cells.
Published Wednesday, May 28, 2014The ATP binding cassette (ABC) transporters are the largest family of transmembrane proteins and involved in conferring multidrug resistance (MDR) to cancers, often causing the failure of cancer treatments. The discovery of Breast Cancer Resistance Protein (BCRP)/...
Investigator(s): Douglas Ross, Doyle L. Austin, Lynne Abruzzo
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): breast cancer, cancer, BCRP, chemotherapy
Docket: DR-97-047
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Novel Opioid Analgesics With Reduced Tolerance
Published Wednesday, May 28, 2014UMB 425 is a novel opioid with bi-functional activity that combines a delta-opioid antagonist and a mu-opioid agonist in a single compound with antinociceptive effects comparable to morphine. With reduced tolerance liabilities, UMB 425 provides a novel therapeutic approach in the treatment of patients who suffer from chronic pain with...
Investigator(s): Andrew Coop, Alexander MacKerell, Rae R. Matsumoto
Categories: Therapeutics, Small molecules
Keyword(s): Opioid, tolerance, analgesic
Docket: AC-2013-055
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Novel Filamentous Hyperstable Chaperone with Protein and Cellular Stabilization
Published Wednesday, May 28, 2014Ethanol, butanol, acetone and many other chemicals have traditionally been employed as a chemical feed stock for a variety of industrial chemicals. However, many of the byproducts produced during fermentation is cytotoxic and limits product generation. The disadvantages of low productivity, low cell density, longer fermentation, and prolonged...
Investigator(s): Frank Robb, Pongpan Laksanalamai, Anchalee Jiemjit, Douglas Clark, Timothy Whitehead
Categories: Engineering, Chemical
Docket: FR-2010-088
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Novel Alternatively Spliced Human Androgen Receptor Variants as Biomarkers for Prostate Cancer
Published Wednesday, May 28, 2014Prostate cancer is the second leading cause of cancer death among men in western countries. Patients with advanced prostate cancer initially benefit from androgen ablation therapy which leads to temporary remission of the tumor due to apoptosis of androgen-sensitive tumor cells. However, the recurrence of androgen-independent tumors is...
Investigator(s): Yun Qiu, Zhiyong Guo, Xi Yang
Categories: Diagnostics
Keyword(s): prostate cancer, biomarker, cancer
Docket: YQ-2008-056
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Natural TFD-Containing Compound Prevents Tumorigenesis
Published Wednesday, May 28, 2014In 2011, prostate cancer was the second leading cause of cancer deaths in men and accounted for approximately a third of all new cases of cancer in the United States. Hormone therapy is the treatment of choice in cases where the primary tumor has metastasized or has advanced to a high-grade, high-risk disease. However, alternative strategies...
Investigator(s): Hafiz Ahmed, Prasan Guha, Engin Kaptan, Gerardo R. Vasta, Gargi Benerjee
Categories: Therapeutics
Keyword(s): natural products
Docket: HA-2011-053
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NON-HEMOLYTIC CLYA FOR PROTEIN EXPORT AND VACCINES
Published Wednesday, May 28, 2014This technology is a specialized protein export system for efficiently producing recombinant protein from a host cell while optimizing safety for use with live vector vaccines, and is related to that described in Docket Code JG-2001-022. The UMB inventors have engineered a genetically stabilized expression plasmid incorporating the protein of...
Investigator(s): James Galen, Yuansha Chen
Categories: Research Tools, Antibodies, & Reagents
Docket: JG-2008-080
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Myo Tak
Published Wednesday, May 28, 2014In the field of striated and smooth muscle biology, the study of the mechanical properties of muscle has relied almost exclusively on multi-cellular preparations (whole muscles or muscle strip preparations). These preparations allow for tying, clipping, or clamping of muscle tissue to mechanical apparatus via tendon or bone attachment. Single...
Investigator(s): Christopher W. Ward, Jonathon Lederer, Benjamin L. Prosser, George Rodney, Luke Michaelson
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: CW-2010-065
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Multivalent Vaccine Against Staphylococcus Aureus
Published Wednesday, May 28, 2014There are nearly 2 million healthcare-associated infections in the U.S. per year, according to CDC-reported statistics. Many of these infections are due to colonization of implantable medical devices with drug-resistant forms of bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). The increasing incidence, morbidity and...
Investigator(s): Mark E. Shirtliff, Jan M. Harro, Jeffrey G. Leid, Rebecca Brady, Graeme O'May
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, staph, Biofilm, MRSA
Docket: MS-2012-065
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Multicellular Organotypic Tissue Engineering of the Human Intestinal Mucosa
Published Wednesday, May 28, 2014The engineering of a three-dimensional (3D) multicellular organotypic model of the human intestinal mucosa has a wide ranging potential as a tool for discovery of both health and diseases, such as interactions with pathogens, antigen trafficking, inflammatory processes, and tissue bioengineering. To more appropriately mimic an in vivo...
Investigator(s): Rosangela Mezghanni, Marcelo B. Sztein, Alessio Fasano
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): intestinal mucosa, Organotypic
Docket: RM-2011-031
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Microcin H47 Plasmid Selection System
Published Wednesday, May 28, 2014The inventors engineered a novel stabilized plasmid selection system incorporating the gene mchI, conferring immunity against a natural antimicrobial peptide called microcin H47, which can be incorporated into the bacterial growth medium. There are no known clinical uses for microcin H47, so this approach is expected to meet vaccine regulatory...
Investigator(s): James Galen, Chee-Mun Fang
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, Microcin
Docket: JG-2007-005