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Overview

Background
Rocuronium is a neuromuscular blocking agent commonly used as general anesthetic during surgery. It is desirable to be able to reverse the effects of rocuronium following surgery for reduced side effects and quick patient recovery. One method to achieve this reversal is the introduction of a molecular container compound capable of strongly and selectively binding to rocuronium. Through chemical binding the rocuronium is removed from the body and the effects of anesthesia are removed. An effective reversal agent would be highly water soluble to allow for intravenous administration using small volumes of liquid.

Innovative Technology
Researchers at the University of Maryland have discovered a new cucurbit[n]uril-type molecular container that meets the requirements for an optimal rocuronium reversal agent. The molecular container has excellent solubility in water ( 100 mM) and binds strongly to rocuronium in water. As such the new molecular container can potentially be used as a reversal agent for rocuronium following surgery. A scalable, efficient, and cost effective synthetic route to this compound has also been developed by these same researchers.

Advantages
- Highly water soluble
- Containers can be produced in scalable quantities at minimal cost

Applications
- Reversal agent for rocuronium following surgery

Contact Info

UM Ventures
0134 Lee Building
7809 Regents Drive
College Park, MD 20742
Email: [email protected]
Phone: (301) 405-3947 | Fax: (301) 314-9502