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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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SMALL MOLECULE STAT3 INHIBITOR FOR TREATING TRIPLE NEGATIVE BREAST CANCER
Published Monday, December 11, 2023Summary The patent application describes the molecule LLL12B which targets STAT3 protein. STAT3 is pivotal in cancer progression. LLL12B is novel therapy that addresses an unmet need in TNBC and pancreatic cancer treatment. The breast cancer therapeutics market, valued at $28.8...
Investigator(s): Jiayuh Lin, Li Pan
Categories: Therapeutics, Small molecules
Keyword(s): • STAT3 Inhibitor, triple-negative breast cancer, pancreatic cancer, Targeted Cancer Therapy
Docket: JL-2022-040
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Compositions and Methods for Delivering Nucleic Acids to Cells
Published Wednesday, December 6, 2023Summary This invention provides a breakthrough in gene therapy and molecular biology, featuring a non-viral vector system for delivering nucleic acids to cells. It utilizes a polyplex particle with acetylated polyethylenimine (Ac-PEI) and an anionic biomaterial envelope, reducing...
Investigator(s): Ryan Pearson and Atanu Chakraborty
Categories: Therapeutics, Biologics, Methods of Treatment
Docket: RP-2020-012
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Silicon Hydrogel Contact Lenses with Embedded Assay Components for Tear Fluid Clinical Assays
Published Wednesday, November 15, 2023Summary The "Silicon Hydrogel Contact Lenses with Embedded Assay Components for Tear Fluid Clinical Assays" patent describes an advancement in non-invasive medical diagnostics. It integrates clinical assay components into contact lenses for real-time tear fluid analysis, catering...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Imaging devices, Diagnostics, Biomarker, Healthcare
Keyword(s): non-invasive monitoring, clinical assays, biomarkers, medical diagnostics
Docket: JL-2021-074
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ANALYTE-SENSITIVE PROBES AND CONTACT LENS FOR DIAGNOSIS OF OCULAR PATHOLOGIES
Published Thursday, November 9, 2023Summary The patent introduces a contact lens integrated with analyte-sensitive probes for diagnosing ocular pathologies through the detection of specific analytes in basal tears. This non-invasive, real-time monitoring technology has applications in medical diagnostics and...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Imaging devices, Diagnostics, Imaging, Healthcare
Keyword(s): Analyte-sensitive probes, fluorescence, Diagnostics, Real-time monitoring
Docket: JL-2019-091
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Silicone Hydrogel Based Fluorescent Assay and Contact Lens
Published Wednesday, November 8, 2023Summary The "Silicone Hydrogel Based Fluorescent Assay and Contact Lens" patent introduces a novel technology for non-invasive medical diagnostics. It integrates a fluorescent assay into a silicone hydrogel contact lens, enabling real-time glucose monitoring in tear fluid. This...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Diagnostics, Biomarker
Keyword(s): fluorescent assay, Glucose Monitoring, analyte detection, biomarker monitoring, diabetes
Docket: JL-2016-128
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One Dimensional Photonic Crystals for Enhanced Fluorescence Based Sensing, Imaging and Assays
Published Monday, November 6, 2023Summary This patent presents a leap in photonic devices, using one-dimensional photonic crystals (1DPCs) to amplify fluorescence in biological assays. The innovation promises a thousand-fold enhancement of evanescent fields, tunable emission, and cost-effective production. It has...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu
Categories: Diagnostics, Imaging
Keyword(s): Photonic crystals, fluorescence enhancement, Bloch Surface Waves, sensing, imaging, assays, dielectric materials, biomolecule detection, real-time quantification.
Docket: JL-2013-117
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Ossicular Prosthesis and Method and System for Manufacturing Same
Published Friday, November 3, 2023Summary This patent describes a personalized medical device, specifically an ossicular prosthesis manufactured via 3D printing, tailored to individual anatomical data from CT scans. The market for such prostheses is growing, driven by the aging population and technological...
Investigator(s): Jeffrey Hirsch, David Eisenman
Categories: Devices, Medical implants, Imaging devices
Keyword(s): Ossicular Prosthesis, 3D printing, Customized Medical Devices, Conductive Hearing Loss, Ossicular Chain Reconstruction, Additive Manufacturing, Biocompatible Materials
Docket: JH-2017-053
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Compositions and Methods for Treating Inflammation and Cancer
Published Thursday, November 2, 2023Summary The patent "Compositions and Methods for Treating Inflammation and Cancer" introduces a novel approach to immunotherapy by modulating the LTβR-NFκB signaling pathways. This technology aims to enhance treatment specificity and efficacy for tissue rejection and certain...
Categories: Therapeutics
Docket: JB-2017-082
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DIAGNOSIS AND PROGNOSIS OF MULTIPLE SCLEROSIS
Published Tuesday, October 31, 2023Summary: The patent introduces a novel method for determining whether an individual with relapsing-remitting multiple sclerosis (RRMS) will experience a relapse or respond positively to specific treatments. By analyzing the ratio of mRNA levels of Response Gene to Complement-32...
Investigator(s): Horea Rus, Cornelia Cudrici, Cosmin Tegla
Categories: Diagnostics, Biomarker
Keyword(s): Multiple Sclerosis, Diagnosis, Prognosis
Docket: HR-2010-081, HR-2015-030
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Compounds and Methods for Addressing Proteotoxicity-Associated Diseases
Published Thursday, July 27, 2023Summary The patent, "Compounds and methods for treating proteotoxicity-associated diseases", introduces a novel approach to combat proteotoxicity - a condition where misfolded or aggregated proteins become harmful...
Investigator(s): Fengtian Xue, Jiou Wang, Tao Zhang, Yu-Ning Lu
Categories: Therapeutics, Small molecules
Keyword(s): Proteotoxicity, Neurodegenerative Diseases, Protein Misfolding, Therapeutic Compounds
Docket: FX-2022-001