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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Novel LRKK2 GTP-Binding Domain Inhibitors for Treatment of Parkinson's Disease and Neuroinflammatory Disorders
Published Tuesday, July 7, 2015Parkinson’s disease (PD) is an age-related disorder affecting an estimated 1-1.5 million Americans. Current therapies are only able to alleviate PD symptoms and aberrant side effects from prolonged use (5-10yrs) of these drugs can parallel the severity of the disease itself. Researchers at the University of Maryland,...
Investigator(s): Wanli Smith, Fengtian Xue, Alexander Mackerell Jr.
Keyword(s): small molecule inhibitor
Docket: WS-2014-161
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Protein-Coated Microspheres for the Treatment of Inflammatory Bowel Conditions
Published Tuesday, June 30, 2015Chronic inflammation of the bowel is estimated to affect over 20% of Americans with only a small subset of individuals being clinically diagnosed with the autoimmune diseases Crohn’s and ulcerative colitis (UC). Researchers at the University of Maryland, Baltimore have developed a targeted therapeutic approach that may be...
Investigator(s): Erik P.H. de Leeuw; Wuyuan Lu
Categories: Therapeutics, Biologics, Methods of Treatment
Keyword(s): microsphere, defensin, inflammatory bowel syndrome, inflammatory bowel disease, Crohn's disease, ulcerative colitis, surface-like protein
Docket: ED-2010-131
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Optimal Sensor Placement of Microphones in Very Large Sensor Arrays
Published Monday, June 22, 2015BackgroundMicrophone arrays, a series of individual microphones operating in tandem for a given area, have a variety of uses including extracting specific sounds from an ambient environment, surround sound recording, and localization, among others. However, using a very large microphone array can be difficult. A very large array will generate...
Categories: Information Technology
Keyword(s): microphone arrays, signal processing, interference minimization
Docket: IS-2013-152
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Biofunctionalized Silk Fibers
Published Thursday, June 18, 2015BackgroundSilk is a versatile natural fiber. It is lightweight and elastic, yet extremely strong, and insect silk has wide use as a fabric. Spider silk has even greater strength and elastic properties but has not found widespread use due to the difficulties of production. The unique properties of spider silk make it an attractive fiber...
Categories: Chemical, Biomaterials, Materials
Keyword(s): 525
Docket: LS-2015-019
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The beta subunit of human hemoglobin (HBB): a Cytostatic/Cytotoxic Peptide for the Treatment of Neuroblastoma Lung Metastases
Published Friday, June 12, 2015A collaborative research project between the University of Maryland, Baltimore and Tel Aviv University has identified a synthetic peptide derived from the beta subunit of hemoglobin (HBB2), which inhibits the propagation of micrometastatic neuroblastomas (NB). In vitro studies have demonstrated that...
Investigator(s): Wuyuan Lu, Isaac P. Witz, and Shelly Maman
Docket: WL-2014-109
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mVermilion: A Novel Red Fluorescent Protein for Dual-Color and Deep Tissue Imaging
Published Wednesday, June 10, 2015mVermilion is a novel, monomeric red fluorescent protein (RFP) based on the structure and characteristics of mCherry. Using a proprietary platform, mCherry was analyzed and significantly modified, resulting in the new protein with approximately two-fold greater brightness and similar excitation and emission spectra. ...
Investigator(s): Mark Rizzo
Keyword(s): fluorescent, TRP, protein, image
Docket: MR-2015-104, MR-2016-092
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Solid Hemoglobin Phantom for Biophotonic Calibration
Published Monday, June 8, 2015Background Tissue-simulating phantoms are valuable tools for researchers and clinicians to calibrate bioimaging devices during preclinical development and research/clinical use over lifetime. The stability and extent to which phantoms mimic human tissues will depend on the materials and methods used in their preparation. Current methods often...
Categories: Imaging devices
Keyword(s): phantom, optical, optical phantom, MRI, ,magnetic resonance imaging, computed tomography, imaging, diagnostic, calibration, positron emission, tissue, Bioimaging, 525
Docket: LS-2015-054
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Biodegradable Polymer Reinforced Pericardium as Hybrid Material for Vascular Grafts
Published Monday, June 8, 2015BackgroundCardiovascular disease is the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030. The direct and indirect cost of cardiovascular diseases and stroke combined total to more than $320.1 billion, including the health and loss of...
Categories: Medical implants, Biomaterials
Keyword(s): Pericardium, cardio, cardiovascular, vascular, implant, hybrid, polymer, calcification, Glutaraldehyde, vascular implant
Docket: LS-2013-138
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Emergency Oxygenation Kit
Published Wednesday, May 27, 2015A few minutes of oxygen deprivation can lead to lifelong brain damage and brain death is inevitable unless blood oxygen levels are restored to normal. Emergency oxygen delivery systems are available for first aid use and can save lives by providing short-term oxygenation until the patient arrives at a medical facility....
Investigator(s): Jeff Wolf, Aldo Iacono
Categories: Devices
Keyword(s): emergency oxygenation, apneic patient, battlefield, Critical Care, Airway Management
Docket: JW-2011-054
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Atomic Layer Deposition Modifications for All Solid State Metal Ion Batteries
Published Tuesday, May 19, 2015Background:Solid-state lithium batteries are considered to be the ultimate solution for an electric vehicle’s power supply which require safety, high energy density, and long a lifespan. Currently high ionic conductive solid state electrolytes and an interfacial contact are the two important issues for the practical use of Solid-state lithium...
Categories: Microelectronics, Engineering, Power Electronics
Keyword(s): batteries, Solid-state ion batteries, metal anode, atomic layer deposition (ALD)
Docket: PS-2015-002