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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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LRP1 Antagonists for Treatment and Prevention of Alzheimer’s Disease
Published Thursday, May 26, 2022Alzheimer’s disease (AD) is a neurodegenerative disease characterized by gradual deterioration of the brain cells and loss of multiple cognitive functions. The cognitive decline in AD is closely linked to aggregated forms of tau which form neurofibrillary tangles (“NFT”) that initiate in the entorhinal cortex...
Investigator(s): Dudley Strickland, Molly Migliorini, Brian Hampton, Joana Cooper, Selen Muratoglu Catania, Bradley Hyman, Aurelien Lathuiliere
Categories: Therapeutics, Methods of Treatment
Keyword(s): Alzheimer’s Disease, Therapeutics, LRP1, Tau, Method, CNS
Docket: DS-2020-052
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NEU1-Selective Sialidase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis
Published Thursday, May 12, 2022Idiopathic Pulmonary Fibrosis (IPF) is an unrelenting, uniformly fatal disease in which lung architecture is distorted and replaced by scar tissue, thereby compromising pulmonary function. IPF patients only survive 2 to 3 years after diagnosis. Although numerous host factors have been implicated in IPF pathogenesis, no unified mechanistic...
Investigator(s): Simeon Goldblum; Irina Luzina; Sergei Atamas
Categories: Therapeutics, Methods of Treatment
Keyword(s): Fibrosis, Therapeutics, IPF
Docket: SG-2019-090
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Optimized Shigella-ETEC Vaccine with Broad-Spectrum Protection
Published Friday, April 22, 2022UMB’s optimized Shigella-ETEC vaccine is designed to provide enhanced & essential protection against the clinically important species & serotypes of Shigella and Enterotoxigenic Escherichia coli (ETEC), the major causes of dehydrating diarrheal illness among children under 5 years old in low to middle-income countries...
Investigator(s): Eileen M. Barry & Myron M. Levine
Categories: Vaccines
Keyword(s): Vaccine; diarrheal disease prevention; travelers
Docket: EB-2018-077
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Method to Preserve Post-radiotherapy Ventilation by Mitigating Radiation-Induced Airway Injury
Published Tuesday, September 7, 2021Preserving post-radiotherapy respiratory function is an important consideration in thoracic radiation therapy. A common limitation of current clinical and investigational approaches that attempt to achieve this objective is that they ignore radiation injury to the elements of the bronchial tree, which are critical to the gas exchange...
Investigator(s): Amit Sawant; Esther Vicente; Arezoo Modiri; Robert Timmerman; Yulong Yan; Henky Wibowo
Categories: Imaging, Healthcare, Methods of Treatment
Keyword(s): Radiation Treatment Planning; Software; Imaging; Oncology; Cancer
Docket: AS-2019-095
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Live Attenuated Non-Transmissible (“LANT”) Vaccines
Published Wednesday, August 18, 2021Non-typhoidal Salmonella (“NTS”) infections are the leading cause of foodborne deaths worldwide, with ~ 80 million (86%) of human NTS infections estimated as foodborne [Majowicz et al, 2010 Clin Infect Dis]. Moreover, multiple outbreaks are reported due to contact with infected animals (e.g., poultry, pigs, cattle, and pets). The...
Investigator(s): Sharon Tennant and James Galen
Categories: Vaccines
Keyword(s): vaccine, salmonella, NTS, AMR
Docket: ST-2019-013
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Deep Depth Estimation on 360-degree Images with a Double Quaternion Loss
Published Wednesday, November 25, 2020Software for training a neural network for depth estimation on 360-degree images.
Docket: 2021-073
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Multi-Beam Optical Phased Array Light Detection and Ranging System
Published Tuesday, August 25, 2020Thermally modulated Nanophotonic Phased Arrays (NPAs) can be used as phase-only holographic displays. Compared to the holo- graphic displays based on Liquid Crystal on Silicon Spatial Light Modulators (LCoS SLMs), NPAs have the advantage of integrated light source and high refresh rate. However, the formation of the desired wavefront requires...
Docket: PS-2020-017
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Treating Optic Nerve Diseases with Neural Stem Cell Factors
Published Thursday, July 30, 2020The optic nerve lamina region (ONLR) is a small junctional region between the eye and optic nerve (ON), and is the primary damage site in age-related eye diseases, such as open angle glaucoma (OAG). Dr. Bernstein’s group at UMB discovered that the ONLR of both human and rodent contains an adult neural progenitor cell (NPC) niche, which...
Investigator(s): Steven Bernstein; Candace Kerr; Sally Temple
Categories: Therapeutics, Stem Cells
Keyword(s): Stem cell; eye disease; glaucoma
Docket: SB-2015-057
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Novel strategies for engineering foreign protein-encoding cassettes into bacterial chromosomal DNA
Published Thursday, November 21, 2019Loss of protein expression is a major problem in protein therapy and live vector vaccination, wherein loss of therapeutic dosage often results in treatment failure. Plasmid DNA, when used as a pharmaceutical agent, allows for real-time protein expression, but is easily lost during bacterial multiplication. In order to achieve sufficiently...
Investigator(s): James E Galen, Jin Yuan Wang
Categories: Vaccines
Keyword(s): vaccine
Docket: JG-2013-037
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Speaker Independent Speech Inversion System
Published Thursday, October 17, 2019BackgroundSpeech inversion is the process of mapping acoustic signals into articulatory parameters. This is a well-known ill-posed problem and the addition of individual speaker differences make it even harder to solve. Normalizing the speaker differences is essential to effectively using multi-speaker articulatory data for training a...
Categories: Software + Algorithm
Docket: IS-2019-031