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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Inhibition of L-Plastin Activity in Osteoclasts to Reduce Bone Loss
Published Monday, March 11, 2019Osteoclasts (OCs) are specialized cell types that develop a focused microenvironment where bone matrix degradation can occur for the process of bone resorption or bone breakdown. Bone breakdown by osteoclasts requires the formation of tight sealing zone or ring in order for efficient focal bone breakdown to occur. L-plastin (LPL) is a...
Investigator(s): Meenakshi Chellaiah
Categories: Therapeutics, Biologics
Keyword(s): osteoporosis bone loss peptide
Docket: MC-2015-066
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A Deformable Lung Motion Phantom
Published Friday, March 8, 2019Motion caused by patient breathing can limit the accuracy of the prescribed dose delivered during radiation therapy (RT) especially for cancers in the thorax and abdomen. Sophisticated respiratory motion prediction and real-time motion modeling have been clinically implemented to improve the accuracy and precision of the dose being delivered to...
Investigator(s): Amit Sawant, Maida Ranjbar, Pouya Sabouri, Carlo Repetto
Categories: Devices
Keyword(s): Radiation Oncology
Docket: AS-2018-044
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Analogs of GHB Lacking GABAergic Activity
Published Monday, February 11, 2019The present invention relates to esthers of 3-hydroxyphenyacetic acid and their use to treat narcolepsy and other sleep disorders. Gamma-hydroxybutyric acid (GHB) is a known agonist for the GHB receptor. Unfortunately it also acts at GABA receptors directly and through its metabolization into alpha aminobutyric acid (GABA). As a result,...
Investigator(s): Andrew Coop, Maharaj Ticku, Charles France
Categories: Therapeutics, Small molecules
Keyword(s): narcolepsy, cataplexy, sleep disorderes
Docket: AC-2006-050
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Noninvasive Characterization of Mechanical Properties of Materials and Tissue using Magnetic Resonance Techniques
Published Wednesday, February 6, 2019Many diseases alter the mechanical properties of tissue. Accordingly, the mechanical properties can serve as biomarkers for disease, diagnosis, and tumor assessment. While some larger diseased tissues or abnormalities near the surface of a patient can be detected by palpitation, many are located deep within the patient or too small to...
Investigator(s): Bruce Yu, Mark Taraban, Yue Feng
Categories: Devices, Software + Algorithm, Sensors/Monitors, Industrial Processing, Other
Keyword(s): MRI, NMR, diagnostic
Docket: BY-2012-013
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Bidirectional Flow Cannula
Published Thursday, January 31, 2019In order to accommodate the high blood flows in veno-arterial extracorporeal membrane circulation (VA ECMO) and cardiopulmonary bypass (CPB), large cannulae are inserted into a patient’s femoral vein, to drain blood to the system, and into the femoral artery to...
Investigator(s): Bartley Griffith, Zachary Kon, Chetan Pasrija, Mehrdad Ghoreishi, Gregory Bittle
Categories: Devices, Medical implants, Surgical devices, Methods of Treatment
Keyword(s): Cardiopulmonary, Life-support, ECMO
Docket: ZK-2017-057
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MITRAL VALVE TRANSLOCATION DEVICE AND METHOD FOR THE TREATMENT OF FUNCTIONAL MITRAL REGURGITATION
Published Thursday, January 31, 2019There is currently no reliable, durable mitral valve repair option for patients with Functional Mitral Regurgitation (FMR). Replacing the mitral valve with a prosthetic tissue or mechanical valve is currently the most durable approach to the treating FMR. However, this procedure has a high perioperative mortality risk and carries the risk...
Investigator(s): James Gammie
Categories: Devices, Medical implants, Surgical devices, Methods of Treatment
Keyword(s): Cardiology, Mitral regurgitation
Docket: JG-2017-025
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A Stable Fibroblast Cell Line To Study Innate Immunity and Host-Viral Interactions
Published Monday, January 28, 2019Background Pathogenic viral infection induced host responses are often driven by specific molecules like interferons. Specific recognition of viral nucleic acids serves as a trigger to stimulate expression of interferons. An essential transcription factor for interferon expression interferon regulatory factor-3 (IRF3) is present in the...
Keyword(s): 525
Docket: LS-2019-002
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Robotic System for Remote Trauma Assessment
Published Sunday, January 27, 2019Background:According to the Center for Disease Control (CDC), trauma from injuries obtained in motor vehicle accidents, gunshots, and unintentional falls are the third leading cause of death in the United States. There exists a short time window, the “Golden Hour”, within which appropriate medical interventions must be employed to...
Keyword(s): Robotics, Robotic assisted Surgery, Robotic ultrasound imaging
Docket: PS-2018-171
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Magnetic nanoparticles in dentistry
Published Thursday, January 24, 2019University of Maryland clinical researchers saw a clear need to target therapeutic agents to dental tissues with a method that would avoid the need for an invasive procedure like a root canal. Drs. Masri and Depireux devised a platform strategy to actively deliver therapeutic payloads to the inner tooth, which relies on magnetic nanoparticles...
Investigator(s): Radi Masri, Didier Depireux
Categories: Devices, Medical implants, Drug delivery devices, Platforms, Materials, Dental
Docket: RM-2014-062
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Novel Method of Internal Organ and Organoid Generation For Therapy and Research in Humans and Animals
Published Wednesday, January 23, 2019Background Advances in stem-cell research have opened up remarkable possibilities for therapeutic and research applications in humans and animals. Stem cells are capable of indefinite proliferation to give rise to either cells of the same type or cells of different tissues in an organism. When combined with gene-editing technologies, the use...
Keyword(s): 525
Docket: LS-2018-059