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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Control of Apoptosis by Controlling the Propensity of Ceramide Channel Formation
Published Wednesday, July 27, 2005Cell researchers believe that the efflux of proteins from mitochondria is an activation event that eventually leads to apoptosis.A number of mechanisms have been proposed for the protein permeation pathway. Candidate mechanisms include the ceramide channels. Researchers at the University of Maryland have a fairly robust model...
Categories: Chemicals, Drug Screen
Keyword(s): ion channels, apoptosis, ceramide
Docket: LS-2005-049
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Metal Impregnated Elastomers as Compliant Electrodes
Published Sunday, July 24, 2005Dielectric elastomer actuators (DEA) respond to electrical stimulation with a shape change, and they can therefore be used as "artificial muscles." DEAs have been shown to expand in area up to 300 percent when high voltage is applied to electrodes on each face of the elastomeric film. These actuators require electrodes that are compliant (...
Categories: Chemical, Microelectronics
Keyword(s): elastomers Dielectric artificial muscle, compliant electrode
Docket: PS-2005-046
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Avian Pneumovirus Subtypes: Potential for Vaccine Development and Diagnostics
Published Sunday, July 24, 2005The U.S. poultry industry continues to thrive because of the high demand for poultry products for direct consumption. However, as the scale of production grows to meet consumer demand, so does the danger of avian viruses and diseases, which can infect and decimate entire flocks of poultry. One of the more troubling and economically devastating...
Categories: Vaccines
Keyword(s): avian
Docket: LS-2004-040
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Formation of Carbon Nanotubes on Large Free Floating Substrates
Published Sunday, July 10, 2005There are several methods employed to make carbon nanotubes. These methods include chemical vapor deposition (CVD), arc discharge and laser ablation. In general, the CVD method has shown the most promise in being able to produce larger quantities of nanotube (compared to the other methods) at lower cost. The CVD method is usually done by...
Categories: Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): carbon nanotube, CVD, nano, 525
Docket: PS-2005-060
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Biological Production of Carotenoids
Published Thursday, June 23, 2005The plant species Adonis aestivalis produces flowers with petals that are deep red in color and nearly black at the base of the petals due to the accumulation of ketocarotenoid and other carotenoid pigments (Neamtu et al., Rev. Roum. Biochim. 6:157, 1969). This pattern of carotenoid accumulation accounts for the common name of some varieties of...
Categories: Natural Compounds
Keyword(s): food supplement, nutrition, fish feed
Docket: LS-98-029
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Force-Feeding Boiling/Evaporation
Published Tuesday, May 17, 2005This invention is directed to a self-contained, two-phase flow system suitable for cooling electronics in a wide range of high flux military and commercial electronic applications. Such a system would find use, for example, in phased array lasers and radars. Currently, micro-fabrication technology has been used for manufacturing heat...
Categories: Microelectronics, Industrial Processing
Keyword(s): capillary pump loop, Heat Flux, 525
Docket: PS-2004-105
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OE-MEMS Chip-Based Mass Sensor for Chemical, Gas, and Bio-Hazard Sensing
Published Sunday, May 15, 2005Currently three methods are used to generate a readout of MEMS cantilever sensors: 1) measurement of the change in cantilever resonance frequency upon mass loading, 2) measurement of the cantilever deflection by reading the laser beam reflection from the cantilever, and 3) measuring the piezoelectric voltage generated by cantilever deflection...
Categories: Chemical
Keyword(s): cantilever sensor, bio sensor, MEMS, VLSI processing detection system
Docket: PS-2005-032
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Optical Interconnect Using a Small Number of Layers
Published Tuesday, May 10, 2005The present invention relates to an optical interconnect fabric operating deep inside a computer system to provide optical co`mmunication between processing elements and memory cells of first level cache.To that effect, the invention is a multi-chip processor/memory arrangement replacing a large computer chip that includes a number of...
Categories: Engineering, Microelectronics
Keyword(s): all optical, 525
Docket: PS-2003-019
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Dynasmart-P
Published Thursday, April 14, 2005DYNASMART-P is one of the two state-of-the-art dynamic network traffic operational planning tools developed under the Federal Highway Administration's (FHWA) Dynamic Traffic Assignment (DTA) research project. DYNASMART-P, developed by researchers at the University of Maryland, supports transportation network planning and traffic operations...
Categories: Information Technology
Keyword(s): 525
Docket: IS-2004-109
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Programmable Selective Deposition of Biofunctional Polymer Surfaces
Published Tuesday, March 15, 2005The ability to create devices such as biosensors, microarrays, and microelectromechnical systems (MEMS) requires facile methods to precisely control surfaces. Microfabrication techniques are routinely applied to create patterned inorganic surfaces with nanometer to micrometer scale resolution. However, traditional approaches such as...
Categories: Biomaterials, Microfluidics
Keyword(s): Microfabrication
Docket: PS-2003-094