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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Dental Nanocomposites and Bonding Agents with Antibacterial Properties
Published Tuesday, May 27, 2014The major clinical problem associated with dental restorations is secondary cary formation and tooth restoration fractures. To address this issue, a new dental resin developed at the University of Maryland, Baltimore, was created to possess superior mechanical strength and antimicrobial properties. The formulation...
Investigator(s): Huakun Xu, Michael Weir
Categories: Dental
Keyword(s): dental, antibacterial, remineralizing
Docket: HX-2010-042 & HX-2012-066
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Defensin-like molecules as novel antimicrobial agents
Published Tuesday, May 27, 2014The ever increasing emergence of many pathogenic strains of bacteria resistant to commonly used antibiotics is a rapidly growing concern in public health and new classes of antimicrobial agents are desperately needed. One approach that has gained popularity recently is to study naturally-occurring antimicrobial peptides that have the advantage...
Investigator(s): Erik de Leeuw, Alexander MacKerell
Categories: Diagnostics, Therapeutics
Docket: ED-2012-088, ED-2010-066
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Coherence-gated Doppler: A fiber sensor for precise localization of blood flow
Published Tuesday, May 27, 2014Coherence Gated Doppler (CGD) is an optical fiber sensor technology that combines the strengths of two optical technologies, the laser Doppler flowmetry (LDF) and the optical coherence tomography (OCT). The current LDF technology remains highly sensitive but suboptimal for localization of flow signals while the OCT and its Doppler variant, DOCT...
Investigator(s): Cha-Min Tang, Chia-Pin Liang, Yu Chen, Ashraf Fouad, Joseph Schmitt
Categories: Devices, Surgical devices
Docket: CT-2013-008
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Clostridium difficile Type IV Pilin As New Target for Vaccine, Therapeutics and Diagnostics
Published Tuesday, May 27, 2014Type IV pilin proteins are extracellular and easily accessible to the host immune system, as well as being important for initial colonization and biofilm formation. Thus, these proteins present excellent targets for vaccines to prevent pathogen colonization. Neutralizing antibodies directed against pili could lead to...
Investigator(s): Michael Donnenberg
Categories: Diagnostics, Therapeutics, Vaccines
Keyword(s): vaccine
Docket: MD-2008-081
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Case Mounting Stabilizers
Published Tuesday, May 27, 2014This device is used for relating casts, molds of the patient's mouth, which are used in the the construction of dentures, partial dentures, bridges, crowns, and implant restorations. No similar product is available, and dentists rely on improvised methods that are not always reliable.
Investigator(s): Sharon Siegel
Categories: Devices, Dental
Keyword(s): dental
Docket: SS-98-042
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Automatic CAD of Meniscal Tears on Magnetic Resonance Imaging: A Morphology- Based Approach
Published Tuesday, May 27, 2014Knee related injuries, including meniscal tears, are common in young athletes and elderly patients, and require accurate diagnosis for optimal treatment. With proper technique and skill, detection rates of meniscal tears are relatively high, but recognition relies on the experience of the physicians and continues to be a challenge for many...
Investigator(s): Nabile Safdar, Bharath Ramakrishna, Chein-I Chang, Wei-min Liu, Khan Siddiqui, Eliot Siegel
Categories: Devices, Imaging devices
Keyword(s): imaging
Docket: NS-2007-085
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Attenuated Strains of SalmonellaTyphi as Mucosal Live Typhoid Vaccines and Expression Vectors
Published Tuesday, May 27, 2014Salmonella enterica serovar Typhi is the cause of typhoid fever, which remains an important public health problem in many parts of the world. Attenuated strains of S. Typhi were engineered by researchers at UMB's Center for Vaccine Development, and selected strains have proven safe and immunogenic in Phase 1 and Phase 2 human trials. The same...
Investigator(s): Fernando Noriega, Myron Levine, Marcelo Sztein
Categories: Therapeutics, Vaccines
Keyword(s): vaccine
Docket: FN-98-001
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Assessing Biopharmaceutical Aggregation Using Magnetic Resonance Relaxometry
Published Tuesday, May 27, 2014Aggregation is a significant problem in biopharmaceutical manufacturing and long-term storage, as aggregated proteins may lose their biological activities, alter concentration, distribution, and kinetics, and aggravate immunogenicity. As the number of biomacromolecule-based, nanoparticle-conjugated, and non-biological...
Investigator(s): Yihua Bruce Yu, Marc Taraban, Yue Feng
Categories: Other
Keyword(s): Quality Control, Biopharmaceutical, diagnostic
Docket: BY-2013-101
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Antimicrobial Heme Oxygenase Inhibitors and Methods of Use
Published Tuesday, May 27, 2014Antimicrobials are widely used to treat a variety of infections. However, due to overuse and microbial evolution, many antimicrobials are rendered ineffective as first-line therapies. This invention is a new class of broad-spectrum, small-molecule antimicrobials that target the critical enzyme, heme oxygenase that is required to process...
Investigator(s): Angela Wilks, Alexander D. MacKerell, Pedro Lopes, Lena M. Furci
Categories: Therapeutics, Small molecules
Keyword(s): antimicrobial, treatment
Docket: AW-2007-003