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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Tick Protein as Vaccine Candidate for Tick-borne Lyme Disease Pathogen
Published Tuesday, April 11, 2017Background: Lyme disease is a vector-borne disease caused by spirochaete Borrelia burgdorferi. By the 2014 Center for Disease Control (CDC) estimates, incidence of Lyme disease has grown in the US from ~11,000 cases reported in 1995 to over 30,000 cases in 2014. Additional literature from NIH places the number of new cases at 300,000 annually...
Keyword(s): Lyme Disease, vaccine
Docket: LS-2016-010
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A Novel Vector to Assay Translational Recoding
Published Tuesday, April 11, 2017Background Translational recoding is a mechanism typically employed by viruses to achieve efficient production of proteins required for assembly and replication. Operationally, translational recoding employs unique 3-dimensional RNA structures that drive ribosomes to slip “out of frame” (Programmed Ribosomal Frameshifting) or to bypass stop...
Keyword(s): ribosomal frameshifting, trasnlational recoding, efficiency monitoring, reporter vector, Fluorescence, quantitative measurement
Docket: LS-2016-091
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Prompt Gamma Imaging System for Proton Range Verification using a Compton Camera
Published Tuesday, April 11, 2017Range uncertainty in the exact position of the distal dose gradient of a proton beam delivered within a patient during radiotherapy (RT) can lead to underdosing of the tumor or to excessive dosing to adjacent healthy tissues or critical organs at risk. The unwanted side effects and complications due this uncertainty is...
Investigator(s): Jerimy Polf, PhD
Categories: Devices, Imaging devices, Software + Algorithm, Healthcare
Keyword(s): Radiotherapy; medical imaging; prompt gamma; compton camera; range verification
Docket: JP-2015-137
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Use of Biomarkers for Assessing Differential Risk for Developing Heart Failure Phenotypes
Published Wednesday, April 5, 2017Left ventricular (LV) hypertrophy (LVH), most commonly due to chronic hypertensive heart disease, is associated with increased risk of developing depressed LV systolic function, heart failure (HF) and death. Routine cardiac imaging to screen for LVH in hypertensive patients is not recommended because...
Investigator(s): Christopher deFilippi, James de Lemos, Robert H. Christenson, Stephen L. Seliger
Categories: Diagnostics, Biomarker
Keyword(s): biomarker, heart failure, Diagnostics
Docket: CD-2014-098
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Recombinant, Purified P. aeruginosa HemO Enzyme
Published Wednesday, April 5, 2017Pathogenic bacteria require iron for their survival and ability to cause infection. Many bacterial pathogens have evolved sophisticated systems to use heme as a primary source of iron, including Pseudomonas aeruginosa, an opportunistic gram-negative pathogen that is a common cause of nosocomial infections and associated with high...
Investigator(s): Angela Wilks
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Heme oxygenase, heme O, TRP, Research Tool
Docket: AW-2015-091
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Surrogate-Based Prediction Model for Real-Time Tumor Monitoring during Radiotherapy
Published Friday, March 31, 2017To ensure tumor-targeting accuracy over the course of radiation treatment while minimizing the dosimetric impact to healthy tissue, respiratory surrogate models are utilized to monitor tumor position while compensating for tumor motion. These models are developed from a training dataset of concurrent tumor positions and...
Investigator(s): Warren D’Souza PhD
Categories: Software + Algorithm, Healthcare, Methods of Treatment
Keyword(s): radiology; medical imaging; image-guided radiation therapy
Docket: WD-2010-069
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Transgenic Ubiquitin (hUBQLN2) Mice Models of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia (ALS-FTD)
Published Monday, March 6, 2017ALS (or Lou Gehrig’s disease) is a progressive neurodegenerative disorder associated with loss of upper and lower motor neurons. A majority of ALS patients (> 90%) die within 2 to 5 years of being diagnosed, usually because of upper respiratory failure. In addition to the hallmark of progressive muscle weakness, up to 15% of patients with...
Investigator(s): Mervyn J. Monteiro
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Molecular Biology; Neuroscience; Genetics; Transgenic mice
Docket: MM-2017-037
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Nano-structured Metal-Enhanced Fluorescence (MEF-spot)-Based Sensing, Imaging and Assay
Published Friday, February 24, 2017This invention describes an improved method for conducting a bioassay using fluorescence intensity or lifetime fluorescent emissions. This new method avoids the need of complex enzymatic and biochemical amplification of the fluorescence signal. Although it has applicability over a wide range of bioassays, the method...
Investigator(s): Henryk Szmacinski, Joseph R. Lakowicz
Categories: Research Tools, Antibodies, & Reagents, Sensors/Monitors
Keyword(s): Cytokine assay, immunoassay
Docket: HS-2012-047, HS-2015-098
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Correction of Ischemia with p53 Inhibitors: A Novel Therapeutic Approach to Induce Arteriogenesis
Published Friday, February 24, 2017Severe obstruction of the arteries and reduced blood flow (critical limb ischemia(CLI)) is the advanced stage of peripheral artery disease (PAD). Investigators at UMB have found that Pifithrin-α, a p53 pharmacological inhibitor, improves limb perfusion in diabetic animals, suggesting a therapeutic role in CLI. Tumor-suppressing...
Investigator(s): Rajabrata Sarkar, Mark Hoofnagle, Subhradip Mukhopadhyay
Categories: Therapeutics, Methods of Treatment
Keyword(s): cardiovascular
Docket: RS-2013-040
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Surgical Drain Sutured-in-Place Prevention Kit
Published Thursday, February 23, 2017After a surgical procedure, a surgical drain is placed within the operative field for proper postoperative drainage of fluids. Complications occur when the sutures used to close the wound encircle or capture the drain, sewing the drain into the patient. Currently, there is no method to assure that a drain is not sewn...
Investigator(s): Douglas J. Turner
Categories: Surgical devices
Keyword(s): Surgical drain
Docket: DT-2013-129