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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Anticancer Compounds Targeted at Secondary DNA Structures
Published Monday, November 24, 2014BackgroundWhile the structure of DNA is most commonly associated with the double helix, research has shown that DNA can adopt many secondary structures for which the biological functions are still being determined. One secondary structure, the G-quadruplex, can form when the double helix unwinds during transcription. One common area for...
Categories: Small molecules
Keyword(s): FLT-3 inhibitor, PARP inhibitor, ALL, ALM, TNBC,
Docket: LS-2014-104
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Repurposed drugs for Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Published Monday, November 24, 2014Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are viral respiratory diseases caused by novel coronavirus strains (SARS-CoV and MERS-CoV, respectively). Categorized as a select agent in 2012, approximately 9,000 cases of SARS have been reported, with 9.5% mortality rate. To date, there have been 1,917...
Investigator(s): Mathew Frieman, Lisa Hensley, Peter Jahrling
Categories: Therapeutics, Small molecules, Chemicals, Repurpose Drug
Keyword(s): MERS, SARS, Repurposed drugs, antiviral drugs
Docket: MF-2014-090
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Surface-Plasmon Enhanced Fluorescence Sensor System
Published Monday, November 17, 2014Fluorescence-based sensing and imaging is widely used in biology. Current detection of fluorescence is determined by the dyes used for labeling, both in microscopy and in gene chips for genomics and proteomics. The disclosed device can be integrated into a commercial fluorescence optical microscope without extra special optical alignment. It...
Categories: Microelectronics, Imaging devices
Keyword(s): Fluorescence sensing, Fluorescence imaging, Plasmonics, bio-sensing
Docket: PS-2006-083
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Immunotherapeutic Potential of Modified Lipooligosaccharides/Lipid A: A Platform for “Custom-designed Adjuvants”
Published Wednesday, November 12, 2014Lipid A, the hydrophobic anchor of lipopolysaccharide (LPS), can stimulate the innate immune system via Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2), leading to the release of inflammatory cytokines/chemokines and type I interferons. In turn, this response increases the host’s ability to eradicate a pathogen and supports...
Investigator(s): Robert K Ernst, Adeline Hajjar, Mark Pelletier
Categories: Platforms, Biologics, Vaccines, Biological, Vaccine, Other
Keyword(s): adjuvant, subunit vaccine, lipid A, platform, lipopolysaccharide, immunostimulation custom synthesis
Docket: RE-2012-067
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Efficient Mechanisms for Thread Handling in Multithreaded Computer Systems
Published Tuesday, November 11, 2014During the 1980s and the early 1990s, quite a few very talented computer science researchers worked on the following problem: Seek the "ultimate" parallel programming model that will allow easy expression of parallel algorithms and their programs in the model, as well as validation of the model by algorithmic paradigms and solutions for as many...
Categories: Information Technology, Software + Algorithm
Keyword(s): parallel computing, multithreading, SIMD, threading, algorithms
Docket: IS-2006-005
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Use of EM 1412 as a vaginal microbicide for HIV, HPV and HSV transmission
Published Friday, November 7, 2014Cervical dysplasia is the existence of abnormal cells in the cervix, which may indicate a pre-cancerous condition. In the United States, 250,000 to 1 million women are diagnosed with cervical dysplasia annually in which 30% to 50% possibly progressing to invasive cancer without treatment. In order to address this issue...
Investigator(s): Niharika Khanna, Neil Frazier, Ru Chi Huang
Categories: Therapeutics, Repurpose Drug, Natural Compounds
Docket: NK-2004-057
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Microdevice for the Detection of Sequence Differences in Biological Samples
Published Tuesday, November 4, 2014BackgroundWith the advancements in biomedical research, accurate sequencing of biological samples is becoming of greater importance. The completion of the Human Genome Project has highlighted the potential of single nucleotide polymorphisms (SNPs) in DNA while the increase in protein-based therapies has increased interest in the...
Categories: Diagnostics, Devices, Research Tools, Antibodies, & Reagents
Keyword(s): Gene sequencing, protein sequencing, lab-on-chip
Docket: LS-2014-076
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3D Printed Molds for 3D Tissue Culture Scaffolds
Published Tuesday, November 4, 2014BackgroundCellular and tissue culture is an important aspect of biological research. Having specific cell or tissue types in a controlled environment allows for development and refinement of the efficacy and safety of biological treatments. However, as researchers study more complex conditions, standard monolayer (2D) cell culture is...
Categories: Biological, Research Tools, Antibodies, & Reagents
Keyword(s): PDMS, stem cells, cell culture, tissue culture
Docket: LS-2014-073
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High Affinity PCR Primer System
Published Tuesday, November 4, 2014BackgroundPolymerase chain reaction (PCR) is a biological research technique for the amplification of DNA sequences that has allowed for great advances in genetics. While PCR techniques have been refined over the years, and there has been continued development of the polymerases used in PCR, there are still some limitations to the...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Genetic testing, PCR primers
Docket: LS-2014-045
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Self-Powered Magnetorheological Dampers
Published Tuesday, November 4, 2014Magnetorheological (MR) fluid-based dampers, which are one of the promising semi-active actuators, have been widely applied to control and suppress unwanted vibration and shock of various systems. Current MR dampers need power sources such as power supply and current amplifier to activate MR fluid inside the damper.Researchers at...
Categories: Aerospace
Keyword(s): Magnetorheological Dampers,shock absorption, Vibration isolation
Docket: PS-2006-080