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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Atomic Layer Deposition Modifications for All Solid State Metal Ion Batteries
Published Tuesday, May 19, 2015Background:Solid-state lithium batteries are considered to be the ultimate solution for an electric vehicle’s power supply which require safety, high energy density, and long a lifespan. Currently high ionic conductive solid state electrolytes and an interfacial contact are the two important issues for the practical use of Solid-state lithium...
Categories: Microelectronics, Engineering, Power Electronics
Keyword(s): batteries, Solid-state ion batteries, metal anode, atomic layer deposition (ALD)
Docket: PS-2015-002
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Portable Multi-Parameter Cancer Diagnostic Device
Published Sunday, May 17, 2015Background: Each year in USA alone, more than 200,000 breast cancer cases are diagnosed. The transformation from benign to cancerous state changes the morphological signatures in the tumor environment. Mechanical and electrical phenotyping has been demonstrated as a promising technique to study the progression of the breast cancer. Thus, a...
Categories: Diagnostics, Platforms, Devices
Keyword(s): breast cancer, Cancer Diagnosis
Docket: PS-2015-017
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Device and Cloud-Based System to Reduce Lower Back Injury in the Workforce
Published Sunday, May 17, 2015Background:A solution to lower-back pain in the workplace needs to be addressed. Lower-back pain is the most common cause of job-related disability and a leading contributor to missed workdays. In fact, the total direct costs of chronic lower-back pain related health care utilization are estimated to be about $100 million a year (Mehra, 2012...
Categories: Devices, Sensors/Monitors
Keyword(s): Back Injury mitigation
Docket: PS-2015-006
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Engineering Thermalization and Chemical Potential for Photons
Published Sunday, May 17, 2015Background:Due to the lack of photon number conservation, in thermodynamics of photons, the chemical potential is absent. However, having a non-zero chemical potential is crucial in understanding a wide variety of single and many-body effects, from transport in conductors and semi-conductors to phase transitions in electronic and atomic...
Categories: Engineering, Chemical
Keyword(s): optomechanics Quantum simulation
Docket: PS-2015-013
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Anti-GRIM-19 antibody
Published Thursday, May 7, 2015Anti-GRIM-19 (1A8) is a mouse monoclonal antibody for detecting Retinoic-Interferon-induced Mortality 19 (GRIM-19) protein. This antibody was raised against the recombinant human GRIM-19 and can recognize both human and mouse GRIM-19. GRIM-19 is widely expressed in humans, with highest expression in heart, skeletal muscle, liver, kidney...
Investigator(s): Dhan V. Kalvakolanu
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): grim, antibody, tumor suppressor, COPD, carcinoma
Docket: DK-2003-050
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Tight junction permeation enhancer peptides
Published Monday, March 23, 2015Human zonulin or pre-haptoglobin 2 (HP2) is known to reversibly regulate intestinal permeability by modulating intercellular tight junctions. Itactivates protease-activated receptor (PAR) 2, and induces signaling...
Investigator(s): Alessio Fasano, Stefanie N. Vogel
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Biologics, Methods of Treatment
Keyword(s): peptides, zot, zonulin, crohns asthma, glioma, celiac disease, type I diabetes, tight junction
Docket: AF-2004-004
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Development and In Vitro Testing of a Novel Trifluoromethylated Cholylsarcosine for assessment of bile acid transport using Fluorine Magnetic Resonance Imaging (MRI)
Published Tuesday, March 3, 2015Biile Acid Malabsorption (BAM) is an underdiagnosed condition in where bile is either not adequately reabsorbed or excessive bile acid is produced causing chronic diarrhea with excess bile acids. In an effort to address this issue, University of Maryland researchers have synthesized a non-radioactive 19...
Investigator(s): Diana Vivian, Jean-Pierre Raufman, James E. Polli
Keyword(s): diagnostic, bile, acid, IBS, BAM
Docket: JP-2014-050
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Biodegradable Oil Spill Dispersant
Published Tuesday, February 10, 2015Background:Dispersants are used to break up an oil slick floating on the surface of water into small droplets that can be carried away by waves. Traditional dispersant formulations contain a blend of surfactants in a base of organic solvent. There are concerns regarding the aquatic toxicity and environmental impacts of current oil-spill...
Keyword(s): corexit nalco macondo gulf coast environment sea life wildlife
Docket: PS-2014-120
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Use of Omentin for Treatment and Prediction of Disease
Published Wednesday, January 28, 2015Obesity, especially accumulation of abdominal fat, is a risk factor for the development of type 2 diabetes and cardiovascular disease. More than one-third of US adults are considered to be obese. Omentin is an adipokine expressed and secreted from abdominal but not subcutaneous...
Investigator(s): Da-Wei Gong, Alan Shuldiner, John McLenithan, Rongze Yang
Categories: Research Tools, Antibodies, & Reagents, Diagnostics, Therapeutics, Biologics, Biomaterials
Keyword(s): omentin, diabetes, obesity, cardiovascular
Docket: DG-2002-013, DG-2007-087, DG-2009-093
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Naturally Derived Herbicide Adjuvants for Glyphosate-Resistant Weeds
Published Monday, November 24, 2014BackgroundGlyphosate (i.e. Roundup®) is a broad-spectrum herbicide that is widely used due to its effectiveness and low toxicity. However, after decades of use, some plants have developed a resistance to glyphosate. These glyphosate-resistant weeds can create economic problems for farmers. For example, the presence of one giant ragweed...
Categories: Natural Compounds, Agricultural
Keyword(s): 525
Docket: LS-2014-162