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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Macroporous Hydrogels for Directed Stem Cell Differentiation
Published Thursday, January 7, 2010Researchers at the University of Maryland have demonstrated that modifications in biomaterial architecture can be used in scaffold design to upregulate endogenous expression of osteogenic growth factors by human mesenchymal stem cells and thus promote bone regeneration. In this approach, mesenchymal stem cells are seeded onto the surface of a...
Categories: Biomaterials, Stem Cells
Keyword(s): cell culture, stem cell differentiation, 525
Docket: LS-2009-104
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Advanced Filtration Media for Treating Urban Stormwater Runoff
Published Tuesday, October 13, 2009BackgroundSand filters are used to remove suspended solids from urban stormwater runoff. These suspended particles are can block sunlight, deposit on organisms, and exert an oxygen demand. They can also carry pollutants such as phosphorus, hydrocarbons, and metals like zinc, copper, and lead. Filtering these particles from urban stormwater...
Categories: Engineering, Clean Technology, Materials
Keyword(s): runoff, pollution, green, pollutants, clean water, filter, filter system
Docket: PS-2009-031
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Therapeutic Nano-Particle Magnetic Injector System
Published Tuesday, October 13, 2009BackgroundMagnetic targeted delivery provides the ability to direct therapeutic substances to different tissues in the body using external magnetic fields. Magnetic targeting makes locations of disease, infection, and cancerous growth more accessible and more treatable with greater efficacy and less cost. A tremendous amount of research has...
Categories: Drug delivery devices, Devices, Engineering
Keyword(s): drug delivery, magnetic drug delivery, magnet, magnetic, cancer, tumor
Docket: PS-2008-116
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Method for Performance-aware Security of Unicast Communications in Hybrid Satellite Networks
Published Wednesday, September 9, 2009Satellite links suffer from longer propagation delays compared to terrestrial links. Most Internet traffic uses the Transmission Control Protocol (TCP), which is highly susceptible to the delay-bandwidth product and exhibits very poor performance in satellite channels as satellite channels have very high bandwidth. Commercial satellite networks...
Categories: Microelectronics, Aerospace, Information Technology
Keyword(s): security,unicast,proxy,authentication
Docket: IS-2008-134
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Bioreactor System for use in Bone and Cartilage Tissue Engineering
Published Sunday, August 30, 2009Researchers at the University of Maryland have developed a novel bioreactor system for bone and cartilage tissue engineering. The system depends on a unique growth chamber configuration that allows for inexpensive, easily manipulated, sterile engineering of bone and cartilage tissue. The growth chamber uses a simple yet elegant design that avoids...
Categories: Bioengineering
Keyword(s): tissue engineering, bone, cartilage, growth chamber, bioreactor
Docket: PS-2009-022
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Genetically Engineered Newcastle Disease Virus as an Oncolytic Agent
Published Monday, July 27, 2009Oncolytic viruses are state of the art for treatment of cancer. Presently non engineered strains of the New castle disease virus are being used in Phase I clinical trial for oncolysis. Researchers at the University of Maryland have developed techniques that offer flexibility to engineer additional therapeutic transgenes in NDV genomes...
Categories: Vaccines, Platforms
Keyword(s): vaccine platform, oncology
Docket: LS-2005-041
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Specific Protein Capture Membranes
Published Monday, July 27, 2009Current approaches to identifying from tissue samples and physiological fluids include immunohistochemistry and blotting, respectively. While there are strengths and weaknesses to both, a common limitation is that they both require large amounts of sample, especially if they are to be used to screen numerous molecular targets (biomarkers). This...
Categories: Platforms, Imaging devices
Keyword(s): High-Throughput, protein binding, biomarker screening
Docket: LS-2005-047
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System Level Synchronization in Communication Systems
Published Monday, July 27, 2009Cyclone technology, developed by Professor Ashok Agrawala et. al, of the University of Maryland at College Park, is a revolutionary approach based on end-to-end protocols to maximize computer-network performance with high stability and efficiency. Utilizing the concept of temporal operations to carry out an end-to-end resource-time allocation,...
Categories: Software + Algorithm, Information Technology
Keyword(s): 525
Docket: IS-2005-064
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Electroacoustic Wave for Enhancing Heat Transport in Nanofluids (Colloids)
Published Monday, July 27, 2009Downscaling or miniaturization has been a recent major trend in modern science and technology. Engineers now fabricate microscale devices such as microchannel heat exchangers and micropumps that are the size of dust specks. Further major advances would be obtained if the coolant flowing in the microchannels were to contain nanoscale particles to...
Categories: Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): Nanofluids, heat transfer, 525
Docket: PS-2005-077
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Mobility Assistive Device With Wide Support Base
Published Monday, July 27, 2009ES Updated /MCBackground Children with neurological disorders, such as spina bifida, often use wheelchairs for mobility to the detriment of their physical development and healthy operation of internal organs. The leg and hip muscles may not be properly innervated so that the child cannot independently ambulate. A mechanical orthotic...
Categories: Devices
Keyword(s): crutch, wide base, arm pit, foot, ambulatory, medical device
Docket: PS-2005-097