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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Techniques for Converting Analog Medical Video to Digital Objects
Published Thursday, May 29, 2014The present invention relates to converting analog medical video data to a digital object that associates descriptive data with the video, and in particular, to forming digital imaging and communications in medicine (DICOM) objects from analog medical video data in a legacy data collection system.
Investigator(s): Paul Nagy
Categories: Software + Algorithm, Healthcare
Keyword(s): medical, video, digital
Docket: PN-2006-047
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Targeting NAD biosynthesis in bacterial pathogens
Published Thursday, May 29, 2014The increasing incidence of antibiotic-resistant pathogens is a major health crisis, particularly in hospital settings in the developed world. It has been estimated that ~70% of hospital-acquired infections involve multi-antibiotic resistant organisms, resulting in ~90,000 annual deaths at a cost of 4.5ý6.0 billion per year (Burke, 2003)....
Investigator(s): Alexander J MacKerell, Hong Zhang, Andrea L Osterman
Categories: Therapeutics, Small molecules
Keyword(s): biosynthesis, pathogens
Docket: AM-2009-069
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Targeted Delivery of Imaging Probes for In Vivo Cellular Imaging
Published Thursday, May 29, 2014Electron paramagnetic resonance (EPR) imaging is a technique for studying molecules that have one or more unpaired electrons, such as organic and inorganic free radicals or complexes with a transition metal ion. EPR may be thought of as analogous to MRI, except that it measures the excitation of electron spins instead of atomic nuclei. Given...
Investigator(s): Joseph Kao, Gerald Rosen, Scott Burks
Categories: Research Tools, Antibodies, & Reagents, Diagnostics
Keyword(s): imaging
Docket: JK-2010-098
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Targeted Conditional Expression of Proteins to Cell-Type
Published Thursday, May 29, 2014Mitochondrial dysfunction has been implicated in the pathogenesis of a plethora of neurodegenerative disorders (e.g., stroke, Parkinson's, amyotrophic lateral sclerosis, Huntington's, Alzheimer's, etc.). However, effective models useful for elucidating mechanisms and therapies associated with neuronal mitochondrial dysfunction are lacking. This...
Investigator(s): Krish Chandrasekaran, Tibor Kristian
Categories: Research Tools, Antibodies, & Reagents
Docket: KC-2006-026
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TWEAK as a Therapeutic Target for Treating Stroke and Other Central Nervous System Diseases
Published Thursday, May 29, 2014Research shows that a TNF-related cytokine known as TWEAK is a causative agent for some of the effects seen in ischemic stroke. When TWEAK binds to a receptor called Fn14 on the surface of neuronal, glial and endothelial cells in the brain, it causes three main effects which result in brain tissue damage: (1) release of pro-inflammatory factors...
Investigator(s): Jeffrey Winkles, Manuel Yepes
Categories: Therapeutics
Keyword(s): stroke, neurovascular
Docket: JW-2005-037
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Techniques for Implementing a Virtual Patient
Published Thursday, May 29, 2014Medical care delivery is a major industry in the United States. An important component of medical care delivery is a cadre of trained medical care professionals who can diagnose patient conditions and prescribe treatment protocols using cognitive skills. The fewer errors made by this cadre, the better the overall quality of medical care is...
Investigator(s): Bruce Jarrell, Sergei Nirenburg, Joan Marjorie McShane, Stephen Beale
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): training, virtual, patient
Docket: BJ-2006-061
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Surgical Abdominal Wall Model
Published Thursday, May 29, 2014The Surgical Abdominal Wall (SAW) model is a physical/mechanical model developed by researchers at UMB to simulate laparoscopic ventral hernia repair (LVHR) and other abdominal wall surgical procedures. Materials were carefully chosen to simulate skin, tissue, organs, and adhesions associated with abdominal wall morphology and pathology....
Investigator(s): Adrian Park, Ivan George, F. Jacob Seagull
Categories: Devices
Docket: AP-2008-024
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Subwavelength Resolution Optical Microscopy
Published Thursday, May 29, 2014Optical microscopy, both transmission and fluorescence, has limited spatial resolution due to well-known limits of diffraction. In addition, few methods are available to increase spatial resolution. The invention describes a novel and a simple method of increasing optical resolution. The present technology can be specifically used to image...
Investigator(s): Joseph Lakowicz, Mustafa Chowdury, Chandran Subanagayam
Categories: Devices, Imaging devices
Docket: JL-2007-088
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Strategy for a Broad-Spectrum Vaccine Against Non-Typhoidal Salmonella
Published Thursday, May 29, 2014On screening sub-Saharan African residents over the last decade for signs of invasive bacterial infection, a high incidence of non-typhoidal Salmonella (NTS) infections was discovered, and these cases were associated with antibiotic resistance and a high mortality of 20-30%. The invasive strains of NTS are dominated by Salmonella Typhimurium...
Investigator(s): Myron Levine, Sharon Tennant, Raphael Simon, James Galen
Categories: Therapeutics, Vaccines
Keyword(s): salmonella, vaccine
Docket: ML-2009-033
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Straight Expandable Polypectomy Forceps
Published Thursday, May 29, 2014Endoscopic biopsy forceps are routinely used for the resectioning of small, sessile, sub-centimeter polyps of the gastrointestinal tract. Originally invented to biopsy and sample mucosa, these forceps remain inadequate for the resectioning of entire polyps and often require multiple passes for complete removal. In order to resolve this issue,...
Investigator(s): Florence M. Aslinia, M.D., MS Eric Goldberg
Categories: Devices, Surgical devices
Keyword(s): device
Docket: FA-2012-062