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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Analyte Sensor Device and miniaturized Gel Holders, Methods and Systems Utilizing the Same
Published Tuesday, May 27, 2014Bioavailable metal ions (e.g. Cu2+, Zn2+) are essential nutrient required for the normal, healthy growth of plants, animals, and humans. Careful monitoring of these ions is often deployed to gauge levels within the environment to ensure safety as well as functionally adequate concentrations for economical utility. To quickly and easily monitor...
Investigator(s): Richard Thompson
Categories: Devices
Docket: RT-2007-027
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1-THP/LDN (low dose Naltrexone) combination as medication for substance dependence disorder
Published Tuesday, May 27, 2014Addiction is a complex and costly disorder that is difficult to treat due to the effects on multiple brain circuits involved in reward and motivation, learning and memory, and inhibitory control over behavior(s). Treatment options remain limited and addiction to alcohol and illicit drugs cause significant problems and economic burden on society...
Investigator(s): Jia Bei Wang, Sarah Sushchyk
Categories: Therapeutics
Keyword(s): Naltrexone
Docket: JW-2012-106
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Biomaterial coatings to Promote Immune Tolerance
Published Tuesday, May 20, 2014BackgroundA primary function of the immune system is to protect the body from foreign pathogens. However, sometimes there are errors in the immune system that cause it to attack and eliminate the body’s own cells – these events are classified as autoimmune reactions. Autoimmunity spans a range of important diseases including multiple...
Categories: Biologics, Biomaterials, Drug delivery devices, Vaccines
Keyword(s): Multiple Sclerosis, lupus
Docket: LS-2014-054
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Targeted Therapeutic Vaccination
Published Thursday, May 15, 2014BackgroundImmunotherapy is a growing field within the health care industry, which focuses on the idea of selectively stimulating or suppressing aspects of a patient’s immune system to enhance or regulate the immune system’s response during a specific disease. Numerous new cancer treatments have come to market that are based on...
Categories: Biologics, Biomaterials, Drug delivery devices, Vaccines
Keyword(s): Multiple Sclerosis, biomaterials, immunotherapy
Docket: LS-2014-053
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Rapid Separation of Bacteria from Complex Samples
Published Wednesday, May 7, 2014BackgroundFoodborne illness in the United States costs billions of dollars each year in health care and other losses. While many of the pathogenic bacteria responsible for foodborne illnesses are known, and testing for them is routine, contaminated food still reaches the consumer. Part of the problem may be due to the length of time...
Categories: Microfluidics, Devices
Keyword(s): Bacteria detection, food safety, Salmonella, E. coli
Docket: LS-2014-071
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Method and Apparatus for Authenticating Biometric Scanners
Published Wednesday, April 30, 2014BackgroundUsing biometrics for authentication of people to systems provides convenience. When authenticating to mobile devices, such as smartphones, tablets and laptops, however, security problems may arise because this authentication typically takes place in unsupervised environments (e.g., at home). Since a mobile device can be easily...
Categories: Information Technology
Keyword(s): biometric scanner, 525
Docket: IS-2011-043
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Treating Cancer with Specific DNA Secondary Structure Binding Compounds
Published Tuesday, April 29, 2014BackgroundWhile the structure of DNA is most commonly associated with the double helix, research has shown that DNA can adopt many secondary structures for which the biological functions are still being determined. One secondary structure, the G-quadruplex, can form when the double helix unwinds during transcription. One common area for...
Categories: Small molecules, Repurpose Drug
Keyword(s): oncogene treatment, cancer, triple-negative breast cancer, pancreatic cancer, lymphoma
Docket: LS-2013-144
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Targeted Delivery System for Therapeutic RNAs
Published Sunday, April 13, 2014BackgroundRNA interference (RNAi) is a powerful tool that has allowed researchers to exert greater control over the expression of genes within cells. With this experimental control over gene expression, researchers have uncovered the mechanisms for numerous diseases that led to the conclusion that RNAi could be a powerful therapeutic...
Categories: Biologics, Drug delivery devices
Keyword(s): genetic modification, fusion protein
Docket: LS-2014-041
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Single Generation Genetic Modification of Large Domestic Animals
Published Sunday, March 30, 2014BackgroundPigs are an economically important agricultural animal and increasingly a coveted biomedical research tool. In recent years, there has been an increasing consensus that the mouse, while still a powerful genetic model species has limitations and cannot fulfill the full spectrum of biomedical demands. As an alternative, large...
Categories: Agricultural
Keyword(s): genetic modification, livestock, disease resistance, animal models
Docket: LS-2014-012
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Method to Create an Optical Waveguide out of Nothing but Air
Published Sunday, March 9, 2014BackgroundLasers are abundant in modern science and culture and have applications in many different fields. Yet the power level delivered by a laser pulse is severely limited by the medium – in many cases, air itself. Both peak power and average power are limited. Peak power is limited by a number of processes including ionization of the...
Categories: Microelectronics
Keyword(s): maser fiber optic communication broadband network cladding refraction index
Docket: PS-2013-115