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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Novel Method of Enhancing Drought Tolerance of Crop Species by Genetic Control of Stomatal Opening and Closure
Published Wednesday, July 13, 2011BackgroundPlants have developed sophisticated mechanisms to cope with and adapt to changes in the environment. For instance, the opening and closing of the stomata (pores found on the leaf surfaces assist in gas exchange and water transpiration, necessary processes for photosynthesis), is tightly regulated via multiple pathways to help...
Categories: Agricultural
Keyword(s): Drought resistance in plants, Drought tolerance in plants, Arabidopsis thaliana, guard cell, stomata, genetic modification
Docket: BI-08-007
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Novel Strategy for Broad-Spectrum Disease Resistance Directed to the Host-Pathogen Interface by RPW8
Published Wednesday, July 13, 2011BackgroundThe severe damage to plants, especially cultivated food and cash crops due to fungal infections has serious economic consequences worldwide. One of the new innovative techniques to combat disease resistance in plants employs the naturally evolved plant disease resistance (R) genes. Most R genes are highly specialized in...
Categories: Agricultural
Keyword(s): disease resistance in plants, RPW8, Haustorium forming pathogens, fungal infections in plants, Powdery mildew resistance protein
Docket: BI-08-005
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Novel Method of Inducing Broad Spectrum Disease Resistance in Plants
Published Wednesday, July 13, 2011BackgroundPlant defense systems cannot be adequately activated upon pathogen attack in plants lacking cognate disease resistant (R) genes. Unfortunately, majority of the commercial crop cultivars possess fewer R genes and are generally more susceptible to pathogens compared to their wild relatives. Utilization of R genes in agriculture...
Categories: Agricultural
Keyword(s): Plant Defense systems, Arabidopsis thaliana, R genes, disease resistance in plants, genetic modification
Docket: BI-04-016
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Novel Influenza Virus Vector for Stable Expression of Recombinant Foreign Genes
Published Tuesday, July 12, 2011BackgroundThe highly variable influenza virus is responsible for the contagious flu that emerges during each winter’s flu season. Flu seasons can be unpredictable and severe. In the span of 30 years, between 1976 and 2006 (for the flu season starting from 1976-1977 to 2006-2007) the estimated range of flu-related deaths ranged from 3,000...
Categories: Vaccines
Keyword(s): Influenza, Influenza vaccine, flu vaccine
Docket: LS-2010-071
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Partial or Complete Plasmid-Free Recovery of Influenza Viruses
Published Tuesday, July 12, 2011BackgroundThere are two kinds of influenza vaccines that are licensed for human use in the United States: an inactivated vaccine and a live-attenuated vaccine virus. The current strategies to produce ideal vaccine candidates are labor-intensive, time-consuming and cumbersome. Therefore, there is an urgent need to develop vaccines that...
Categories: Vaccines
Keyword(s): Influenza vaccine, Plasmid-free, Seasonal and pandemic influenza
Docket: LS-2011-047
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Egg-Based Dietary Supplement for the Prevention and Treatment of Infectious Diseases
Published Tuesday, July 12, 2011BackgroundInfluenza vaccination significantly reduces the morbidity and mortality of seasonal influenza. However, its efficacy is limited in high-risk populations such as infants, the elderly and the immunosuppressed. The lack of preexisting immunity to pandemic or zoonotic (spread from animals to humans) strains can lead to severe...
Categories: Natural Compounds
Keyword(s): Influenza vaccine, vaccine, Egg-based dietary supplement, Prevention and Treatment of Infectious diseases, Infectious diseases
Docket: LS-2011-046
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Everything We Say It is: Essential Water
Published Tuesday, July 12, 2011BackgroundWater based products with vitamins, minerals and other nutrients have a wide-ranging niche in the marketplace. These products are not only ideal for consumers interested in having a sugar-free or reduced sugar drink but also for disadvantaged groups in desperate need of a wholesome and easily consumable nutritive drink. The...
Categories: Natural Compounds
Keyword(s): Water based nutridrink, nutri-drink, nutridrink, vitamin water, fat-soluble vitamin water
Docket: LS-2011-028
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Novel Anti-Malaria Strategy using Transgenic Fungi
Published Tuesday, July 12, 2011BackgroundMalaria is a life-threatening infectious disease caused by parasites that are transmitted to people through the bites of infected mosquitoes. In 2008, an estimated 190 - 311 million cases of malaria occurred worldwide and 708,000 - 1,003,000 people died, most of them young children in sub-Saharan Africa (CDC). The currently...
Keyword(s): Malaria, Anti-malarial, Plasmodium falciparum, Metarhizium anisopliae, mosquito, transgenic fungi, Filariasis and Dengue, mosquito-borne parasitic infections, integrated vector management
Docket: LS-2011-026
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Diagnostic Assay to Study Protein-Nucleic Acid Interactions
Published Tuesday, July 12, 2011BackgroundProtein-nucleic acid interactions including protein-DNA and protein-RNA interactions are crucial to the protection and usage of the genome. There are many methods currently being used to identify and analyze these interactions including filter binding assays, eletrophoretic mobility shift assays (EMSA), Chromatin...
Categories: Research Tools, Antibodies, & Reagents, Platforms, Drug Screen
Keyword(s): Protein-nucleic acid interactions, Protein-DNA interactions, Protein-RNA interactions, High-Throughput, Protein-ligand interactions
Docket: LS-2011-021
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Tunable Nanoparticle Array
Published Sunday, May 15, 2011BackgroundSurface-enhanced Raman scattering (SERS) is a spectroscopic and analytic technique that achieves extreme sensitivity through the strong coupling between electromagnetic radiation, plasmon modes of a surface, and electronic states of molecule, which in turn couple to the vibrational modes of the molecule. SERS substrates are often...
Categories: Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): SERS, nanoparticle, optical, magnetic, environmental
Docket: PS-2011-008