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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Stable Fluorescent Mutant of Perkinsus marinus Expressing GFP
Published Tuesday, May 2, 2017Perkinsus are intracellular parasites that cause disease in shellfish, especially bivalve molluscs. Its infection has devastated oyster populations along the US coasts. In addition to the economic value of shellfisheries, filter-feeding bivalves such as oysters play a critical role in maintaining water quality, making Perkinsus...
Investigator(s): Gerardo R. Vasta, Jose-Antonio Fernandez-Robledo
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Transgenic, protozoan
Docket: GV-2014-015
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A Novel Salmonella Strain For Vaccinating Chicken
Published Wednesday, April 12, 2017Background Salmonella outbreaks among poultry flocks result not only in direct losses to the farmer but also indirect costs to the entire industry due to loss of consumer confidence at the break of news about an outbreak. According to Center for Disease Control (CDC), 8 known outbreaks resulted in the US in 2016 alone. The passage of...
Keyword(s): Salmonella vaccine, chicken, poultry, 525
Docket: LS-2016-186
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A Nanomaterial Platform For Auto-immune Disease Therapy
Published Wednesday, April 12, 2017BackgroundThe immune system protects the body from foreign pathogens. However, errors in the immune system can cause attacks on and elimination of the body’s own cells - called autoimmune reactions - the primary cause behind multiple sclerosis, rheumatoid arthritis, certain types of allergies, and asthma. Such reactions are also relevant...
Keyword(s): autoimmune disease, Multiple Sclerosis, therapy, Therapeutic
Docket: LS-2016-175
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Electrical Actuation of Cellular Gene-Expression
Published Wednesday, April 12, 2017Background Transgene-technology is a method that introduces a foreign gene (transgene) into a cell and forces the production of specific proteins that drive desired biological functions, with outcomes such as diagnosis and therapy in humans, improved crop varieties and yields in plants, efficient protein production in bacteria, and other...
Keyword(s): synthetic biology, implantable, wearable, Diagnostics, engineered cells
Docket: PS-2016-168
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Novel Biomaterial Platform to Promote Antigen-specific Tolerance During Auto-immune Disease Therapy
Published Wednesday, April 12, 2017Background A recent report from American Autoimmune Related Diseases Association and National Coalition of Autoimmune Patient Groups estimates the disease burden of autoimmune disorders to be >$50 billion. A major disadvantage in the immunosuppressive treatments to autoimmune disorders is the non-specific suppression of immune system exposing...
Keyword(s): auto-immune disorders, Therapeutic, Multiple Sclerosis, rheumatoid arthritis
Docket: LS-2016-139
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Rapid, Inexpensive Point-of-Care Measurement of Oxidative Stress in Biological Samples
Published Wednesday, April 12, 2017Background Oxidative stress, the imbalance between the production of free radicals as part of normal metabolism and the body’s ability to neutralize through various natural antioxidants, has been implicated in numerous pathological conditions. Such conditions include neurodegenerative diseases, cardiovascular disease, and cancer. While...
Keyword(s): oxidative stress, schizophrenia, Diagnostics
Docket: LS-2016-134
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A Probiotic Strain For Nutritional and Therapeutic Use
Published Wednesday, April 12, 2017Background Probiotics- single or mixed cultures of live microorganisms with the ability to confer health benefits to host upon dietary consumption- emerged as functional foods with enormous market potential (>$4-5 billion). Several products with such live cultures are currently available in the marketplace. However, susceptibility to viral...
Keyword(s): probiotics, phage-resistant, normal flora, pathogenic bacteria
Docket: LS-2016-124
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A Biodegradable and Less Toxic Alternative to Lead Removal From Water
Published Wednesday, April 12, 2017BackgroundThe World Health Organization (WHO) estimates that lead poisoning contributes to 0.6% of the global disease burden in terms of disability adjusted life years (DALYs). Food and drinking water are chief sources for lead poisoning, which can be remediated through elimination of lead use, improved monitoring, and preventive mechanisms...
Keyword(s): Lead-toxicity, pollution, water, Filtration, lead-poisoning, hydrogel, biodegradable, lead-removal
Docket: LS-2016-047
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Engineered quantum dots as therapeutic vehicles and research reagents
Published Wednesday, April 12, 2017BackgroundQuantum dots(QDs) are ultra-small colloidal nanoparticles that have unique properties for in vivo imaging, diagnostics, and delivery of drugs and therapeutics. Prior research has employed quantum dots for in vivo targeting and imaging in cancer and the central nervous system. Rational surface modification of quantum dots with...
Keyword(s): Multiple Sclerosis, auto-immune disorders, immune tolerance, antigen-specific tolerance
Docket: LS-2016-036
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Targeting plant hormone metabolism to promote growth and development in deficient conditions
Published Tuesday, April 11, 2017Background: Auxins are plant growth hormones that play a crucial role in developmental processes that include gametogenesis, embryogenesis, seedling growth, vascular patterning, and floral development. Understanding biodegradation of auxins will help uncover novel targets to spatio-temporally modulate the hormone levels thereby...
Keyword(s): plant growth, high yields, seed size, plant size, rooting, delayed bud opening, 525
Docket: LS-2016-014