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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Microcin H47 Plasmid Selection System
Published Wednesday, May 28, 2014The inventors engineered a novel stabilized plasmid selection system incorporating the gene mchI, conferring immunity against a natural antimicrobial peptide called microcin H47, which can be incorporated into the bacterial growth medium. There are no known clinical uses for microcin H47, so this approach is expected to meet vaccine regulatory...
Investigator(s): James Galen, Chee-Mun Fang
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, Microcin
Docket: JG-2007-005
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Methylated Peptides Derived from Tau Protein and Their Antibodies for Diagnosis and Therapy of Alzheimer's Disease
Published Wednesday, May 28, 2014Alzheimer's disease (AD) is a neurologically degenerative disease that is defined in part by the accumulation of aberrant tau proteins (neurofibrillary tangles) within the brain. The mechanisms which drive tau aggregation is not fully understood and existing treatments do little to delay the inevitable decline of Alzheimer's patients. UMB...
Investigator(s): Jyanyu Austin Yang, Stefani N. Thomas, Jeffrey A. Kuret, Kristen E. Funk
Categories: Diagnostics, Therapeutics
Keyword(s): Alzheimer, AD
Docket: AY-2012-036
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Methods of treating obstructive lung diseases using bitter tastants
Published Wednesday, May 28, 2014Asthma, an obstructive lung disease and the most common chronic condition among young children, affects ~20 million Americans, causing more than 4,000 deaths each year. Researchers have discovered a method for treating asthma and related obstructive lung diseases using bitter taste agonists as bronchodilators. This invention was made possible...
Investigator(s): Stephen Liggett, Deepak Deshpande, Wayne Wang
Categories: Therapeutics
Keyword(s): lung diseases, asthma, chronic
Docket: SL-2010-062
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Methods for Regulating Urinary Potassium
Published Wednesday, May 28, 2014Potassium is the most abundant intracellular cation. It is critically important for many physiologic processes, including maintenance of cellular membrane potential, homeostasis of cell volume, and transmission of action potentials in nerve cells. Small changes in the extracellular potassium level can have profound effects on the function of...
Investigator(s): Paul Welling, Liang Feng
Categories: Therapeutics, Small molecules, Biologics
Keyword(s): Urinary Potassium, potassium
Docket: PW-2008-072
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Method for the identification of microbial community signature as diagnostic markers, including specific applications for the diagnosis of Crohn's disease and ulcerative colitis.
Published Wednesday, May 28, 2014The two most common forms of inflammatory bowel disease (IBD), are Crohn's and ulcerative colitis, disease states in which the body elicits an immune response within the gastrointestinal tract causing chronic pain, inflammation, and intestinal distress. Though distinctly different, the two diseases often share common symptoms making a...
Investigator(s): W. Florian Fricke, James White
Categories: Diagnostics
Keyword(s): Crohn's disease, ulcerative colitis
Docket: WF-2012-079
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Method for Teaching and Evaluating decision-Making Skills Through Computer-Based Simulation
Published Wednesday, May 28, 2014Researchers in the Department of Surgery, University of Maryland School of Medicine, have developed a software tool to aid faculty in teaching students clinical decision-making in patient care as well as the interrelationships between medicine and other disciplines. The software is used to design medical case studies of patients that recreate...
Investigator(s): Bruce Jarrell, Craig Skinner, John Raczek, Noble Jarrell, John Flowers
Categories: Software + Algorithm, Healthcare, Education/Training/Multimedia
Keyword(s): Computer-Based Simulation, simulation, teaching, evaluating
Docket: BJ-2004-032
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Method and Assay for Early Diagnosis of Prostate Cancer
Published Wednesday, May 28, 2014For well over 20 years, digital rectal examination (DRE) combined with the measurement of prostate specific antigens (PSA) have remained the most recommended screening tests for the detection of prostate cancer for men over 40. However, both exams remain highly unreliable due to the high prevalence of false positive and negative results. To...
Investigator(s): Hafiz Ahmed, Gerardo Vasta
Categories: Diagnostics
Keyword(s): prostate cancer, cancer
Docket: HA-2010-082
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Melanoma Oncolytic Virotherapy by the HSV-2 Mutant delta-PK
Published Wednesday, May 28, 2014Oncolytic viruses are replication-conditional viruses with relative tumor selectivity and are a therapeutic strategy designed to reduce tumor burden by direct cell lysis; however, their modest clinical efficacy may be related to poor virus replication within the tumors. The present invention is based on the hypothesis that virotherapy...
Investigator(s): Laure Aurelian, Aric Colunga, Jennifer Laing
Categories: Therapeutics, Biologics
Keyword(s): Melanoma, Virotherapy
Docket: LA-2009-096
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Medication Management Instrument for Deficiencies in the Elderly (MedMalDE)
Published Wednesday, May 28, 2014Denise Orwig and Nicole Brandt at University of Maryland Baltimore, have developed a questionnaire for the use of nonmedical personnel (untrained caregivers such as family members, volunteers, or staff aides) to assess an older adult's ability to manage medications in the home setting.
Investigator(s): Denise Orwig, Nicole Brandt
Categories: Software + Algorithm, Healthcare
Keyword(s): software, education
Docket: DO-2002-045
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Medical Image Registration and Applications
Published Wednesday, May 28, 2014Hardware-accelerated image registration has been developed by Dr. Raj Shekhar's group at UMB, a novel computing solution for automatic and accurate registration (spatial alignment) of three-dimensional medical images of any modality and any anatomy. Using these innovations, the computing period for image registration is considerably shorter (...
Investigator(s): Raj Shekhar
Categories: Devices, Imaging devices
Keyword(s): medical image
Docket: RS-2006-006