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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Small Molecule Inhibitors of BCL6
Published Thursday, May 29, 2014BCL6 is a transcription factor essential for germinal center B-cell development. The BTB domain (also known as the POZ domain) is a common protein-protein interaction motif that is found in over 180 human proteins including BCL6 and has been implicated in many biological processes including central nervous development, oocyte maturation, eye...
Investigator(s): Alexander Donald MacKerell, Jr., Ari M. Melnic, k Gilbert G. Prive
Categories: Therapeutics, Small molecules
Keyword(s): small molecules
Docket: AM-2007-053
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Small Molecule Inhibitors Of Kynurenine 3-Monooxygenase
Published Thursday, May 29, 2014Kynurenic acid has neuroprotective activities in vivo while the metabolic byproduct of kynurenic acid, quinolinic acid, is neurotoxic. Kynurenine 3-monooxygenase catalyzes the conversion of kynurenine into 3-hydroxykynurenine, a precusor of neurotoxic quinolinic acid. In light the properties of kynurenic acid and quinolinic acid,...
Investigator(s): Robert Schwarcz, Paulo Guidetti
Categories: Therapeutics, Small molecules
Docket: RS-2007-032
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Salmonella Based Oral Vaccines for Anthrax
Published Thursday, May 29, 2014Recent heightened awareness of the possibility of bioterrorism has raised concerns about the use of Bacillus anthracis or related strains as bio-weapons. Anthrax is an infection caused by the spore-forming bacterium B. anthracis, which can enter the body and cause infection by means of inhalation, ingestion, or subcutaneous exposure. There is a...
Investigator(s): Leslie Baillie
Categories: Vaccine
Keyword(s): Anthrax, vaccine, salmonella
Docket: LB-2010-092
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SILCS: Site Identification by Ligand Competitive Saturation. Method for binding site identification by molecular dynamics simulation
Published Thursday, May 29, 2014The present invention is directed to a method of computational chemistry for identifying binding sites by molecular dynamics simulations using ligand competitive saturation. Fragment-based drug discovery relies on a simple premise: identify small molecule fragments that bind to a target region of a large molecule and then evolve or link the...
Investigator(s): Alex MacKerell Jr., Olgun Guvench
Categories: Research Tools, Antibodies, & Reagents, Software + Algorithm
Keyword(s): simulation, drug design
Docket: AM-2009-054
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Real-time tracking of tumor motion during radiation treatment using a dynamic couch
Published Thursday, May 29, 2014A patient couch is designed to track movement of a target tumor in the patient (due to biological functions such as respiration), and to make compensatory moves so that the radiation treatment site is stabilized.
Investigator(s): Warren DýSouza, Xinsheng Yu, Mohan Suntharali, William Regine
Categories: Devices, Imaging devices
Keyword(s): radiation, tumor
Docket: WD-2005-055
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Radiology Protocoler
Published Thursday, May 29, 2014The Radiology Protocoler is a centralized, web-based system for automatically tracking, editing, and storing existing medical radiology documents and files both automatically and on demand. The web-based design allows the system to be accessed from within a hospital, radiology practice, or through a virtual private network (VPN). Modularity...
Investigator(s): Ross Filice, Wayne LaBelle
Categories: Software + Algorithm
Keyword(s): radiology, software
Docket: RF-2010-078
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Prostaglandin D2 metabolites for treatment of optic nerve diseases
Published Wednesday, May 28, 2014Blockage of blood supply to part or all of the optic nerve within the eye can lead to death or dysfunction of optic nerve cells and is termed non-arteritic ischemic optic neuropathy (NAION). NAION is the most common cause of sudden optic nerve related vision loss and affects about 10,000 Americans every year. Currently there is no effective,...
Investigator(s): Steven Lance Bernstein
Categories: Therapeutics, Biologics
Keyword(s): eye, Ophthalmology, stroke, ischemia, neuroprotection, orphan
Docket: SB-2008-026
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Pluripotent Stem Cell Production Method
Published Wednesday, May 28, 2014One of the major hurdles in stem cell research is that techniques for purification and propagation can be tedious and result in low yields. Standard methods require feeder cells, matrix, and serum, which are expensive and can introduce contaminants. UMB researchers, however, have developed an alternative method to consistently and reliably...
Investigator(s): G. David Trisler, Bernard M. Pessac, Christopher T. Bever Jr., James E. Goolsby
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Stem Cells
Keyword(s): stem cell
Docket: GT-2004-009
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Plasmid maintenance system for antigen delivery
Published Wednesday, May 28, 2014For live bacterial vaccines, various plasmid-based expression technologies may be utilized to express foreign antigens from the host bacteria. Keys to success using such systems include the need to achieve adequate antigen production to generate a good immune response, while reducing toxicity that may be associated with the foreign protein, and...
Investigator(s): James Galen
Categories: Therapeutics, Vaccines
Keyword(s): vaccine
Docket: JG-98-002
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Peptide Additives to Enhance the Acceptance and Consumption of Baits by Rodents
Published Wednesday, May 28, 2014Rodenticides are used to control rodent pests in residential, industrial and agricultural settings. Neophobic responses to unfamiliar food types, micro-sampling and learned poison shyness are factors that reduce bait acceptance by target rodents, reducing their effectiveness. It has been shown that Rodents exhibit a...
Investigator(s): Steven Munger
Categories: Clean Technology, Other
Keyword(s): peptide, rodent, rodenticide, behavior
Docket: SM-2013-065