Search Technologies
Displaying 401 - 410 of 885 results
Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
Search by keyword:
-
Manometry Monitoring Device for Use in Virtual Colonoscopy (VC) Examinations
Published Wednesday, May 28, 2014Virtual colonoscopy (VC) is an effective medical procedure for use in identifying polyps and cancers in the bowel. Typically, this procedure involves cleansing the patient's bowel, distending the patient's colon by insufflation, scanning the patient, and analyzing the acquired images. However, the proper amount of distention following...
Investigator(s): David Vining
Categories: Devices, Imaging devices
Keyword(s): Virtual Colonoscopy, colonscopies
Docket: DV-2007-108
-
MINIR: Minimally Invasive Neurosurgical Intracranial Robot
Published Wednesday, May 28, 2014Brain tumors are the second leading cause of cancer-related deaths in children and the most feared complication of metastatic spread. The unfavorable location of many tumors, usually deep or otherwise inaccessible to conventional neurosurgical techniques, places patients at an undue risk for neurological complications from complex brain surgery...
Investigator(s): Rao Gullapalli, Jaydev P. Desai, J. Marc Simard, Mingyen Ho
Categories: Devices, Surgical devices
Keyword(s): brain tumors, tumor
Docket: RG-2012-008
-
Lower extremity gain scores (LEGS)
Published Wednesday, May 28, 2014The LEGS is a portable performance-based assessment designed to assess recovery after a hip fracture by providing concrete norms that can serve as benchmarks over the course of recovery.
Investigator(s): Jay Magaziner, Sheryl Zimmerman, William Hawkes, J. Richard Hebel
Categories: Software + Algorithm, Healthcare
Keyword(s): hip fracture, LEGS
Docket: JM-2003-019
-
Live Attenuated Salmonella Paratyphi A Vaccine
Published Wednesday, May 28, 2014With the emergence of antibiotic resistant strains and increase in frequency of enteric fever caused by Salmonella enterica serovar Paratyphi A, there is a critical need for a prophylactic vaccine, as none is currently available. Typhoid fever and paratyphoid fever are clinically indistinguishable, patients having a rash and fever which can...
Investigator(s): Chris Vindurampulle, Eileen Barry, Myron Levine
Categories: Vaccine
Keyword(s): vaccine, paratyphoid
Docket: CV-2006-034
-
Vaccine for Prevention of Sepsis and Broad Protection Against Gram-Negative Bacterial Infections
Published Wednesday, May 28, 2014The “J5dLPS/OMP” vaccine, created by academic and federal research collaborators led by Prof. Alan Cross, is a clinical-stage vaccine for the prevention of sepsis and protection against infection by a wide variety of Gram-negative bacteria. The vaccine comprises detoxified core lipopolysaccharide from Escherichia coli J5 complexed with...
Investigator(s): Alan Cross, Apurba Bhattacherjee, Wendell Zollinger, Steven Opal
Categories: Vaccine
Keyword(s): vaccine, gram-negative infection, sepsis prevention
Docket: AC-2006-005
-
Injectable Matrix for Load-Bearing Bone Repair
Published Wednesday, May 28, 2014Dr. Huakun Xu and his team at UMB have created an injectable and mechanically strong construct to be used with or without stem cells for bone tissue engineering. The UMB inventors have designed a strong, moldable, and injectable stem cell-containing scaffold for bone tissue engineering that can be used in...
Investigator(s): Huakun Xu, Michael Weir
Categories: Bioengineering, Dental
Keyword(s): bone repair, dental
Docket: HX-2010-041 & HX-2012-027
-
Inhibitors of S100 Proteins for the Treatment of Cancer and Other Diseases Involving Uncontrolled Cell Growth via an S100-Dependent Pathway
Published Wednesday, May 28, 2014Small molecules have been identified, using rational drug design, that bind to a site on S100 proteins, rendering S100 incapable of inactivating p53 tumor suppressor protein. Inhibitors of S100 thus restore tumor suppressor activity of the p53 protein by inhibiting the S100-p53 interaction. Inhibitors are specific to different members of the...
Investigator(s): David Weber, Joseph Markowitz, France Carrier
Categories: Diagnostics, Therapeutics, Small molecules
Keyword(s): tumor, cancer, S100 proteins, research tools
Docket: DW-2002-041
-
Inhibitors of Extracellular Signal-Regulated Kinase (ERK) regulated signaling pathways
Published Wednesday, May 28, 2014This technology is a set of novel ATP-independent, extracellular signal-regulated kinase (ERK) inhibitors that have the potenital to provide specific targeting compared to existing ERK1/2 inhibitors. The lead ATP-independent ERK inhibitor candidates, interact with specific ERK substrate...
Investigator(s): Paul Shapiro, Stephen Fletcher, Alex MacKerell
Categories: Therapeutics, Small molecules
Keyword(s): Signal-Regulated Kinase, ERK
Docket: PS-2013-025,PS-2013-054
-
Inhibitors of Cell Migration and Shape Changes by Inhibiting Cortactin and HS-1 Mediated Actin Polymerization
Published Wednesday, May 28, 2014The present invention is a novel approach to suppress metastasis by targeting cortactin (or HS-1), an actin -associated protein. Cortactin is overexpressed in breast cancer and head and neck carcinomas where it plays a major role in tumor progression by promoting metastasis. Preventing binding of cortactin (or HS-1) to Arp2/3 blocks actin...
Investigator(s): Xi Zhan, Takehito Uruno
Categories: Therapeutics, Small molecules
Keyword(s): neck carcinomas, head carcinomas, cancer
Docket: XZ-2005-108
-
TLR Inhibitors for Treatment of Influenza, Cancer, Allergy, Inflammation and Prevention of Endotoxic Shock
Published Wednesday, May 28, 2014The Toll-like receptors (TLRs) play a vital role in eradicating pathogenic microbial infections, eliminating necrotic host cells and enhancing tissue repair in the host. On the flip side, chronic TLR activation leads to inflammatory disease and “systemic” activation of TLRs may lead to death. ...
Investigator(s): Vladimir Toshchakov
Categories: Research Tools, Antibodies, & Reagents, Platforms, Therapeutics, Biologics
Keyword(s): TLR, decoy peptides, inflammation, cancer, microbial infections, immune disorders, allergy, endotoxic shock, TRAM, TRIF, TIRAP and MyD88
Docket: VT-2012-029 VT-2012-052