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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Heterodyne Ambient Condition Kelvin Probe Force Microscopy (HAC-KPFM)
Published Wednesday, September 16, 2015Background:Kelvin probe force microscopy (KPFM) adapts an atomic force microscope to measure electric potential on surfaces at nanometer length scales. The original amplitude-modulation Kelvin probe force microscopy (AM-KPFM) method has been used to study numerous phenomena; such as pn junctions, Langmuir films, and crystal orientation of...
Keyword(s): 525
Docket: PS-2015-110
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Topical Treatment for Gonorrhea
Published Wednesday, August 26, 2015BackgroundGonorrhea is the second most common notifiable infection in the United States. While there are treatments available for gonorrhea, resistance to these antibiotics is developing, and lasting gonorrheal infections can result in reproductive complications including infertility in women. Resistance is developing to current...
Categories: Biologics, Small molecules
Keyword(s): Infectious disease, sexually transmitted disease, preventative medicine
Docket: LS-2015-111
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Modified Proteobacterial Enzyme for Industrial and Medicinal Applications
Published Wednesday, August 26, 2015BackgroundNaturally derived and modified enzymes have been used for a variety of biological and non-biological applications. Sea weed and bacteria derived polysaccharide, aliginate has been used in food as thickening or gelling agent, and as a stabilizer; alginate hydrogels have applications in the drug delivery and wound healing areas (...
Categories: Biologics, Industrial Processing
Keyword(s): alginate, alginate lyase, enzyme, bacterial enzyme, bacteria, sea weed, proteobacteria, bioremediation, biofilm, antibiotic, antimicrobial,industrial, Therapeutic, food, food processing, marine, catheter
Docket: LS-2014-086
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Use of Micro-RNA Mimics as Therapeutic Agents for Inhibition of Neuronal Apoptosis Following Traumatic Brain Injury.
Published Tuesday, August 25, 2015Reduced blood flow to the brain due to thrombosis, embolism, cardiac arrest, or injury, can result in focal or global cerebral ischemia. Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and subsequent neuronal death. Ischemia can have irreversible sequela. Post-injury treatment to curtail cell death due to acute...
Investigator(s): Alan Faden, Bogdan Stoica, Boris Sabirzhanov
Categories: Therapeutics, Small molecules, Biologics
Keyword(s): Traumatic Brain Injury, micro RNA, miRNA mimics, ischemia
Docket: AF-2014-011
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Compositions and Methods for Determining the Likelihood of Appendicitis
Published Tuesday, August 25, 2015Appendicitis is a condition that is easily treated through the surgical removal of the appendix. However, delays in diagnosis beyond 24-36 hours from the start of symptoms can lead to an increased risk of mortality, morbidity, and costs due to complications. Diagnosis is complicated by the heterogeneous clinical presentation of...
Investigator(s): Anthony Sandler, Claire M. Fraser, Emmanuel Mongodin, Hope Jackson, Katherine Davenport, Steven L. Zeichner
Categories: Diagnostics, Biomarker, Genomics/Proteomics/Database
Keyword(s): Appendicitis, Appendix, Microbiota, bacteria
Docket: CF-2014-074
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Gonorrhea Vaccine
Published Wednesday, August 19, 2015BackgroundNeisseria gonorrhoeae (GC), the causative agent of the sexually transmitted infection gonorrhea, is the second most common notifiable infection in the United States. Untreated GC infections can result in reproductive complications in women. Fortunately, there are antibacterial treatments available for gonorrhea. However,...
Categories: Vaccines
Keyword(s): Infectious disease, sexually transmitted disease
Docket: LS-2015-100
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A Novel Method for Production of Rare Carotenoids from Commercially Available Lutein
Published Tuesday, July 21, 2015Anhydrolutein, a-cryptoxanthin, b-cryptoxanthin and zeaxanthin are among the 12 major dietary carotenoids which are found in human serum, milk, major organs, and tissues. Industrial production of a wide range of purified carotenoids is of great importance in view of the role of carotenoids in the prevention of chronic diseases like cancer, age-...
Categories: Natural Compounds
Keyword(s): Nutraceutical
Docket: LS-2000-040
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Synthesis of Lutein
Published Tuesday, July 21, 2015BackgroundLutein is a dietary carotenoid present in most fruits and vegetables and has been shown to play an important role in eye health and the prevention of age-related macular degeneration (AMD). These health benefits make it an important dietary supplement. However, currently lutein is commercially produced by extracting it from...
Categories: Natural Compounds
Keyword(s): Nutraceutical
Docket: LS-2008-036
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Early Identification and Prediction of Exploits Using Social Media
Published Monday, July 20, 2015The number of software security vulnerabilities discovered in recent years has grown significantly. Several of these vulnerabilities, such as Heartbleed and Shellshock, became widely known and reported. However, when these exploits become publicly known, malicious users can create exploits of their own based on known information. Therefore, it is...
Keyword(s): malware, exploits, cybersecurity
Docket: IS-2015-045
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Improving Smartphone Battery Life with Cooperative Relaying on LTE Networks
Published Monday, July 13, 2015BackgroundAs smartphones, tablets, and other mobile devices have become more powerful and cheaper, devices that communicate through cellular networks have become prevalent, if not ubiquitous. However, the utility of these devices are limited by battery life, which has grown at a much slower pace than processing capability, and data...
Categories: Software + Algorithm, Information Technology, Clean Technology, Clean Tech
Keyword(s): 525
Docket: IS-2014-170