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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Inhibition of Breast Cancer Metastases using Natural Extracts from Colocasia Esculenta (Taro).
Published Wednesday, May 28, 2014Studies link breast cancer, the second leading cause of cancer-related mortality in US women, with the occurrence of metastatic disease and spread. However, the majority of current therapies focus on the treatment of solid tumors with very little focus on targeting the metastatic process. Due to the significant correlation of secondary tumors...
Investigator(s): Namita Kundu, Amy Fulton
Categories: Therapeutics, Biologics, Natural Compounds
Keyword(s): breast cancer, cancer
Docket: NK-2009-001
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Inhibition Of Metastatic Tumors
Published Wednesday, May 28, 2014Cancer is the second-leading cause of death in the United States. Death of cancer patients is most often caused by metastatic spread of tumor cells from the primary tumor site through the bloodstream where the cells lie dormant for long periods. These dormant cells will invade secondary sites such as the lung, liver or kidney where they develop...
Investigator(s): Stuart Martin, Rebecca Whipple, Agnes Cheung
Categories: Devices, Imaging devices, Software + Algorithm, Healthcare, Education/Training/Multimedia
Docket: SM-2006-059
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Noninvasive Aortic Blood Pressure Measurement for Prediction of Cardiovascular Disease Risk
Published Tuesday, May 27, 2014BackgroundCardiovascular disease (CVD) is the number one cause of death in the US and the world, with an estimated 32.8% of deaths in the US having cardiovascular (CV) related factors. Ailments such as hypertension, atherosclerosis, myocardial infarction (heart attacks), and heart failure are all related to CVD. There are many ways of...
Categories: Healthcare, Diagnostics
Keyword(s): Cadiovascular disease, clinical, blood pressure, healthcare, heart disease, medical device
Docket: IS-2013-088
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Dynamic Searchable Encryption with Minimal Data Leakage
Published Tuesday, May 27, 2014BackgroundDynamic Searchable Symmetric Encryption (DSSE) methods are used to perform searches on encrypted data without decryption. This allows for the secure storage of data on remote or third-party storage while maintaining the ability for the user to access data as needed. However, current DSSE schemes have drawbacks that make practical...
Categories: Information Technology
Keyword(s): Cloud, big data, symmetric encryption, data storage, encrypted searching
Docket: IS-2014-035
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IL-25 treatment of obesity and metabolic disorders
Published Tuesday, May 27, 2014Obesity is associated with chronic low grade inflammation in adipose tissues, mainly due to the accumulated immune cells (Th1/Th17 cells, macrophages etc.) that release pro inflammatory cytokines into the system. These cytokines contribute to development of the “metabolic syndrome.” IL-25 is an important regulator in the...
Investigator(s): Aiping M. Zhao, Terez Shea-Donohue
Categories: Therapeutics, Biologics
Keyword(s): IL-25, Biologic, Therapeutic
Docket: AZ-2011-020
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High affinity recombinant sea lamprey antibodies selected by a yeast surface display platform.
Published Tuesday, May 27, 2014Immunoglobulin-based antibody therapeutics are enjoying unprecedented success. Hundreds are in clinical trials, with revenues from the top five (Rituxan, Remicade, Herceptin, Humira, and Avastin) increasing from $6.4 billion in 2004 to $11.7 billion in 2006 (Dimitrov & Marks, 2009). Thousands more are available for biological detection...
Investigator(s): Zeev Pancer, Roy Mariuzza, Satoshi Tasumi, Carlos Velikousky
Categories: Diagnostics, Platforms
Docket: ZP-2010-085
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HSP90 as a Biomarker for Malignancies
Published Tuesday, May 27, 2014Heat Shock protein 90 (Hsp90)` a molecular chaperone` has shown to have a great potential as an anti-cancer target. Hsp90 antagonists (e.g. 17AAG) have emerged as promising drugs that inhibit tumor cell growth by affecting the ability of Hsp90 to fold associated molecules important in cancer growth and progression. The invention relates to...
Investigator(s): Angelika Burger, Edward Sausville
Categories: Diagnostics, Biomarker
Docket: AB-2007-015
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Fluorescence-Based Assay to Screen for Mitochondrial Protective Compounds
Published Tuesday, May 27, 2014The UMB inventors have developed an enzymatic assay which is a sensitive method for detecting mitochondrial damage. It is based on coupled enzymatic reactions that produce a detectable fluorescence signal in the presence of the reduced or oxidized form of nicotinamide adenine dinucleotide (NADH/NAD) and can detect nanomolar levels of pyridine...
Investigator(s): Tibor Kristian, Gary Fiskum
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: TK-2004-007
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Electrosurgical Element and Uterine Manipulator for Total Laparoscopic Hysterectomy
Published Tuesday, May 27, 2014During total laparoscopic hysterectomy (removal of the uterus and cervix by a minimally invasive method, TLH), separation of the uterus and the cervix from the vagina remains one of the most difficult and cumbersome steps of the procedure. This patent pending invention is a device that will simultaneously allow the surgeon to manipulate the...
Investigator(s): Vadim Morozov
Categories: Devices, Surgical devices
Keyword(s): device
Docket: VM-2009-082
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040