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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Solar Water Heater
Published Wednesday, October 20, 2010BackgroundSolar water heaters are environmentally-friendly, energy saving devices. Unfortunately, they are also often expensive, heavy, and difficult to install. A typical solar water heater is made of a metallic material including an absorbent device, a copper tube containing aluminum fins, which functions as a heat exchanger, and a...
Categories: Clean Tech
Keyword(s): solar, alternative energy, portable, water heater
Docket: PS-2010-093
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Color Changing Polymer Detects Chemical, Biological Threats
Published Wednesday, October 13, 2010BackgroundChemical and biological warfare agents and homemade explosive devices (HMEs) threaten the safety of soldiers and law enforcement officials. These agents, which may include Ricin, Sarin, and Soman, and HMEs, such as nitroglycerin and triacetone triperoxide (TATP), can be difficult to detect. Foodborne pathogens can also be...
Categories: Imaging, Biomarker
Keyword(s): public health, food safety, pathogens, chemical and biological warfare
Docket: LS-2010-079
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Universal High-Throughput Detection of Protein-Ligand Interactions
Published Monday, October 11, 2010BackgroundThe knowledge of protein-ligand and protein-metabolite interactions has significant implications in modern drug design and use. Since each of these molecular interactions represents a potential pharmaceutical intervention in disease and agriculture, there is an urgent need to collect qualitative and quantitative functional...
Categories: Research Tools, Antibodies, & Reagents, Drug Screen, Platforms
Keyword(s): Protein-Ligand Interaction, Diagnostic Kit to study Protein Ligand Interaction, Diagnostic kit, Biomolecular Interactions
Docket: LS-2010-086
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Noninvasive Neural Decoding of Human Bipedal Locomotion
Published Monday, October 11, 2010In the past two decades, significant advancements have been made in the development of wearable robots or “exoskeletons” for medical rehabilitation training (restoration of walking and running after spinal cord injury, for example), and for motor performance enhancement applications in which the exoskeleton is not permanently integrated with the...
Categories: Microelectronics, Robotics
Keyword(s): exoskeleton, non-invasive, bipedal locomotion, spinal cord injury
Docket: PS-2010-072
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Platform for Oral Delivery of Peptide and Biological Therapies
Published Monday, October 11, 2010BackgroundOral administration of nutritional supplements, therapeutics, and other agents represents the most desirable route of delivery to the systemic circulation. Its advantages over the invasive intravenous delivery include increased patient compliance, reduced costs and flexible dosing regimen. However, in many cases, implementation of...
Categories: Drug delivery devices
Keyword(s): drug delivery, Bioavailability, GI Tract, Gastrointestinal Tract, Therapeutic, Systemic Circulation
Docket: LS-2010-050
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Novel Therapeutics to Treat Giardiasis
Published Sunday, September 12, 2010IntroductionThe human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common waterborne diarrheal diseases worldwide. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. Furthermore, Giardia infections contribute substantially to the 2.5 million annual deaths from...
Categories: Small molecules
Keyword(s): Giardiasis, Giardia lamblia, Anti-Protozoal Drugs, Anti-Giardiasis Drugs, Giardiasis Infections, Protozoal Infections, Fumagillin
Docket: LS-2010-052
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For Low Light Imaging, CMOS Sensors Take the Lead
Published Wednesday, September 8, 2010For sensitive low light imaging applications, photomultiplier tubes (PMTs) have been the quality gold standard for their superior noise performance and robust single-photo detection capability. Unfortunately, PMT arrays are large, expensive, delicate, and lack high spatial resolution. Alternatively, complimentary metal-oxide-semiconductor (CMOS...
Categories: Imaging devices, Microelectronics
Keyword(s): CMOS image sensors, dark current reduction, Low-light sensing
Docket: PS-2010-053
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Novel Membrane and Catalysts for Portable Alkaline Fuel Cells
Published Thursday, September 2, 2010BackgroundProton exchange membrane fuel cells (PEMFC) have been extensively investigated for possible commercial use as a next generation power source. However, the high cost of PEMFC electrolyte membranes and catalysts has hindered development. Many scientists have therefore turned to alkaline polymer electrolyte fuel cells (APEFC) and...
Categories: Chemical
Keyword(s): fuel cell, Portable Power Source, catalyst
Docket: PS-2010-070
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Introducing Artificial Cilia NEMS – The World’s Smallest Flow Rate Sensors
Published Wednesday, July 21, 2010Microfluidic flow rate sensors and actuators have been transformational in the fields of life and biomedical sciences. Current flow sensing strategies like optical or image velocimetry, thermal anemometry, and micro-electromechanical (MEMS) cilia or hair inspired sensors with diameters on the order of 10-100 micrometers only provide limited flow...
Categories: Microfluidics, Nanotechnology + Nanoparticles + Nanomaterials, Sensors/Monitors
Keyword(s): NEMS microfluidic flow sensing actuator
Docket: PS-2010-046
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Phosphorylated and Branched DPD Analogs as Quorum Sensing Inhibitors in Bacteria
Published Tuesday, May 25, 2010BackgroundAntibiotic resistance is a critical issue plaguing public health. The development of alternative antimicrobial therapies like Quorum Sensing inhibitors could be an effective solution. Quorum Sensing (QS) is a bacterial cell to cell communication system used by decentralized group of bacteria to coordinate behavior including motility...
Categories: Small molecules
Keyword(s): Quorum Sensing, Antibiotic Resistance, Quorum Quenching Analogs, AHL Inhibitors, Phosphorylated Branched DPD (Dihydroxy-pentane-dione), AI-2 analogs, QS Antagonists, biofilm, Bacterial Pathogenicity, Antimicrobial therapies
Docket: LS-2010-005