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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Novel Method of Internal Organ and Organoid Generation For Therapy and Research in Humans and Animals
Published Wednesday, January 23, 2019Background Advances in stem-cell research have opened up remarkable possibilities for therapeutic and research applications in humans and animals. Stem cells are capable of indefinite proliferation to give rise to either cells of the same type or cells of different tissues in an organism. When combined with gene-editing technologies, the use...
Keyword(s): 525
Docket: LS-2018-059
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Monoclonal antibodies inhibiting fibrin-VLDL receptor-dependent inflammation
Published Tuesday, January 22, 2019Fibrin is a fibrous, non-globular protein involved in blood clotting and promotes leukocyte transmigration through its interaction with the endothelial cell receptor, the very low density lipoprotein (VLDL) receptor. The VLDL receptor is predominantly expressed in the heart, skeletal muscle, fat, brain and macrophages and involved in neural...
Investigator(s): Leonid Medved, Sergiy Yakovlev, Dudley Strickland
Categories: Therapeutics, Biologics
Keyword(s): Cardiology, antibody, inflammation, fibrin
Docket: LM-2016-049
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Business of Startups (Workbook)
Published Thursday, January 17, 2019This innovative workbook guides aspiring startup founders through the essential steps of turning an idea into a business. Written by experts from the University of Maryland’s own Dingman Center for Entrepreneurship and informed by Lean Startup methodology, The Business of Startups features easy-to-follow explanations and activities that make...
Docket: IS-2018-130
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Programmatic Interface to Digitimer DS8R and Compatible Devices
Published Wednesday, January 9, 2019This software library is a programmatic interface that allows for the control of various settings of the DS8R Biphasic Constant Current Stimulator produced by Digitimer Ltd. and other compatible devices. This interface consists of two parts. The first part is a wrapper API that interacts with DLL supplied by Digitimer. The second part uses...
Categories: Software + Algorithm
Docket: IS-2018-155
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libASPP: The Asynchronous Standard Parallel Port Library
Published Tuesday, January 8, 2019The Asynchronous Standard Parallel Port Library (libASPP) is a module developed at the University of Maryland that asynchronously sends various event signals to other devices for data synchronization. The asynchronous signal transfer feature is implemented using a multiple timer queue, which allows the sender to process its algorithms and data...
Categories: Software + Algorithm
Docket: IS-2018-118
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Improved Antifungal Peptides for Candida Infections
Published Tuesday, November 27, 2018BackgroundOral thrush is an infection with a high incidence in patients with a suppressed or not fully developed immune system (e.g., HIV-infected, cancer, and newborns). A common cause of oral thrush is Candida albicans, which colonizes mucosal surfaces in healthy people, but can cause oral thrush and other infections in...
Keyword(s): 525
Docket: LS-2017-026
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General Synthesis and Assembly of Inorganic Chiral Nanostructures with Tunable Chirality
Published Sunday, November 4, 2018BackgroundChirality (or handedness) is the property of an object to be non-superimposable to its mirror image. Right and left hands, for example, are composed of the same components but are distinguishable from each other. Chiral chemical compounds, by extension are composed of the same elements in the same proportions but are distinguishable...
Keyword(s): Inorganic Chiral Compounds, Inorganic Nanostructures, Inorganic Chiral Synthesis
Docket: PS-2017-087
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Dialysis Driven Real-Time PCR with Surface Enhanced Raman Spectroscopy in a Thermoplastic Chip
Published Thursday, September 27, 2018BackgroundOver the past decade, there has been a push for the use of microfluidic devices as ideal point of care of diagnostic tools as a result of their portability and simplicity. These devices allow for the manipulation of small volumes of liquid in microfabricated channels thereby, facilitating the analyses of disease biomarkers such...
Keyword(s): 525
Docket: PS-2017-153
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Membrane Displacement Traps for Droplet Discretization and Manipulation
Published Thursday, September 27, 2018BackgroundMicrofluidics is a class of technology where the precise manipulation of fluids in very small channels and devices leads to improved devices in fields as different as medical diagnoses and inkjet printing. A subclass of microfluidic technology is Droplet-based Microfluidics where instead of manipulating a continuous flow,...
Keyword(s): 525
Docket: PS-2017-121
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Confidence-Based Robotic Surgery
Published Monday, September 24, 2018Robotic assisted surgery (RAS) was mainly developed to facilitate minimal invasive surgery by leveraging on the dexterity and precision of programmed tools. The features of this technology allow for smaller incisions, shorter hospital stays and faster wound healing, these benefits being very popular amongst patients, surgeons and insurance...
Keyword(s): Robotic assisted Surgery, Shared control
Docket: PS-2018-056