TECHNOLOGYAnti-shark IgNar mouse monoclonal (GA8) antibody
Overview
The cartilaginous fish (sharks, skates, and rays) have a human-type adaptive immune system as well as immunoglobulins (Igs). In addition to the heavy-light chain heterodimeric isotypes (IgM and IgW), sharks also produce a novel isotype called IgNAR. IgNAR is a heavy chain homodimer that does not associate with light chains. Its variable (V) regions act as independent, soluble units in order to bind the antigen.These heavy chain ONLY or “single-domain” antibodies have potential as therapeutic tools.
UMB researchers have developed an anti-shark IgNar mouse monoclonal antibody that can be used as a research tool to monitor immune responses in sharks.
Publication: A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1775-80.
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