TECHNOLOGYBroad spectrum antibacterial therapeutic peptides of probiotic origin
Overview
Bacterial diarrhea still remains the second leading cause of deaths globally, accounting for one fifth of all deaths among children under five. Small bioactive peptides with both Gram-positive and Gram-negative bactericidal activity have been isolated from Lactobacillus GG. These peptides have broad-spectrum antibacterial properties against enteric bacterial pathogens. Of the 7 peptides isolated and characterized by the inventors, the peptide NPSRQERR showed the highest antibacterial potency, both for Gram-negative and Gram-positive bacteria. Additionally, these peptides are thermostable, which enhances their stability during manufacturing, processing and storage. These peptides show strong efficacy against Gram-negative (Escherichia coli EAEC 042 and Salmonella typhi) and somewhat lesser potency against Gram-positive (Staphylococcus aureus) bacteria.
A suitable peptide formulation for delivery to gastrointestinal tract needs to be addressed before possible clinical applications.
Publication(s):
Lu R et al, J Pediatr Gastroenterol Nutr. 2009 Jul; 49(1): 23-30
Licensing Potential
Available for licensing
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