Overview
Bacterial diarrhea still remains the second leading cause of deaths globally, accounting for one fifth of all deaths among children under five. Small bioactive peptides with both Gram-positive and Gram-negative bactericidal activity have been isolated from Lactobacillus GG. These peptides have broad-spectrum antibacterial properties against enteric bacterial pathogens. Of the 7 peptides isolated and characterized by the inventors, the peptide NPSRQERR showed the highest antibacterial potency, both for Gram-negative and Gram-positive bacteria. Additionally, these peptides are thermostable, which enhances their stability during manufacturing, processing and storage. These peptides show strong efficacy against Gram-negative (Escherichia coli EAEC 042 and Salmonella typhi) and somewhat lesser potency against Gram-positive (Staphylococcus aureus) bacteria.
A suitable peptide formulation for delivery to gastrointestinal tract needs to be addressed before possible clinical applications.
Publication(s):
Lu R et al, J Pediatr Gastroenterol Nutr. 2009 Jul; 49(1): 23-30
Licensing Potential
Available for licensing
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