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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Nanoparticle-Based Artificial Antigen Presenting Cell for the Modulation of Natural Killer T (NKT) Cells
Published Thursday, February 23, 2017Natural killer T (NKT) cells constitute an important subset of T cells that can both, directly and indirectly, mediate antitumor immunity. It has been reported that the number of NKT cells in cancer patients can be 47% lower than those found in healthy patients. An effective mean of generating populations of NKT cells would be therapeutically...
Investigator(s): Tonya Webb, James East, Carolyn Morris
Categories: Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): Cancer Immunotherapy, adaptive immunotherapy
Docket: TW-2012-105
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Individually Optimized Uniform Enhancement in Contrast Enhanced Computed Tomography (CT) Scans
Published Thursday, February 23, 2017CT has become the primary method for to evaluate for pulmonary embolism (PE). However for CT to be diagnostic, uniform contrast enhancement of the pulmonary arterial tree is desired. Obtaining uniform contrast enhancement is difficult because there are numerous factors involved. There are methods for calculating the correct injection rate for...
Investigator(s): Ming Xue, Hao Howard Zhang, Seth Kligerman, Warren D. D’Souza, Wei Lu, Wookjin Choi
Categories: Software + Algorithm
Keyword(s): radiology
Docket: MX-2013-110
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Delay Belt Device: A Fall Prevention System
Published Thursday, February 23, 2017Injuries related to falls are a major source of morbidity and mortality and come with a significant financial burden to the health care system. This technology, a delay belt device (DBD) with electronic control features, provides a straightforward and complete solution to this problem. The DBD is an integrated electronic safety device that can...
Investigator(s): Michael Makley
Categories: Devices
Keyword(s): Healthcare device
Docket: MM-2012-077
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Protein-Repellant Compositions to Inhibit Protein Absorption and Bacteria Attachment for Dental Applications
Published Thursday, February 23, 2017The mechanism underlying dental caries is demineralization through the attack by acid generated by acidogenic bacteria. Acidogenic bacteria growth typically occurs in plaque and biofilm. When biofilms forms at the tooth restoration margins, the demineralization of the enamel and dentin leads to secondary caries, restorative material fractures,...
Investigator(s): Huakun Xu, Ning Zhang
Categories: Medical implants, Dental
Keyword(s): Dental devices, Antibacterial materials
Docket: HX-2014-154
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Multi-Functional Fluid Flow Device
Published Tuesday, February 21, 2017Cells within a body are exposed to interstitial fluid movements that stimulate morphologic and biochemical cell changes in response to their environment. The fluid flow device is an inexpensive, multifunctional adapter that fit the wells of traditional tissue culture plates to introduce fluid flow shear stress and...
Investigator(s): James Lyon, Joseph Stains, Christopher Ward
Categories: Research Tools, Antibodies, & Reagents, Microfluidics
Keyword(s): Microfluidics, Research Tool
Docket: JL-2016-052
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Determination of Site of Origin Ventricular Tachycardia
Published Wednesday, February 15, 2017Cardiac ablation (CA) is one of three procedures used to treat ventricular tachycardia (VT). CA procedurescan take 6 or more hours to complete. The length of the CA procedure is highly dependent on how quickly the surgeon can pinpoint the VT site of origin (VTSO). The University of Maryland, Baltimore (UMB) researchers have developed a patented...
Investigator(s): Magdi M. Saba, Stephen R. Shorofsky
Categories: Imaging devices
Keyword(s): Cardiac mapping
Docket: MS-2007-102
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Cyber Disruption Index and Framework
Published Tuesday, December 20, 2016BackgroundCurrently, there is no method of measuring and categorizing cyber threats and disruptions. As a result policy makers are unable to push for reforms that would adequately address the malicious cyber activity. Organizations have had difficulty dealing with these types of threats. Innovative TechnologyResearchers at...
Keyword(s): 525
Docket: IS-2016-083
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Simetric
Published Monday, December 19, 2016BackgroundChildren undergoing medical procedures experience stressful reactions that can impair treatment and recovery. Currently, hospitals employ various methods to reassure these children, including showing them the treatment room and talking them through the procedure. However, some hospitals lack the necessary resources to accomplish...
Categories: Software + Algorithm, Engineering
Keyword(s): virtual reality, procedure, stress, anxiety, treatment
Docket: IS-2016-073
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Health and Disease Monitoring in the Heart and the Aorta based on Model-Based Ballistocardiogram Analysis
Published Thursday, November 17, 2016Background: Ballistocardiogram (BCG) is a direct consequence of how the heart ejects blood, thus its waveform can have a lot to do with the cardiac function. Many efforts have been made to mathematically relate the abnormalities in the BCG waveform to heart disease. However, the existing technologies only qualitatively explain the coupling...
Keyword(s): 525
Docket: IS-2015-163
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Treatment of depression, anhedonia, chronic stress conditions and PTSD with (2R6R)-HNK
Published Thursday, November 10, 2016Ketamine exerts rapid and sustained antidepressant effects after a single dose in patients with depression, but its use is associated with undesirable side effects. With the novel discovery of the actions of ketamine metabolites on the AMPA and not the NMDA glutamate receptors as previously reported,...
Investigator(s): Todd Gould, Panos Zanos, Irving Wainer, Carl Zarate, Craig Thomas, Patrick Morris, Ruin Moaddel
Categories: Therapeutics, Small molecules
Keyword(s): Therapeutic, depression, CNS
Docket: TG-2015-116, TG-2016-107