Search Technologies
Displaying 351 - 360 of 885 results
Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
Search by keyword:
-
Oral live-vector vaccine against Clostridium difficile-associated disease
Published Thursday, May 29, 2014UMB researchers have achieved significant clinical success with live vector vaccines based on attenuated Salmonella enterica serovar Typhi (proven safe in clinical trials). Adapting these typhoid vaccine strains for the delivery of foreign antigens offers exceptional flexibility for further vaccine development. Dr. Jim Galen's group devised...
Investigator(s): James Galen
Categories: Vaccines
Keyword(s): vaccine, C. difficile, oral
Docket: JG-2009-032; JG-2013-037
-
Vaccine Enabling Technologies
Published Thursday, May 29, 2014Bacterial live vector vaccines represent a strategy offering exceptional flexibility for vaccine development. In this approach, genes that encode foreign antigens of unrelated bacterial, viral, or parasitic pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby...
Categories: Bioengineering, Vaccine
Keyword(s): vaccine
Docket: Multiple Docket Numbers
-
Use of Trehalose for Prevention of Neural Tube Defects
Published Thursday, May 29, 2014The neural tube is a specialized part of the embryo that forms the skull, brain and spinal cord in adults and requires an effective balance between cell death and survival. Disruption of this process causes neural tube defects (NTDs) such as spina bifida, anencephaly, and encephalocele. UMB researchers have discovered Trehalose treatment...
Investigator(s): Peixin Yang, E. Albert Reece
Categories: Therapeutics, Small molecules
Keyword(s): Trehalose, diabetes
Docket: PY-2012-118
-
Use of Tight Junction Antagonists in the Treatment of Acute Lung Injury and Acute Respiratory Distress
Published Thursday, May 29, 2014Acute Respiratory Syndrome (ARDS) is a severe, life-threatening condition, present in about 150,000 individuals in the US annually with an alarming mortality rate of 30-50% in those affected. To treat ARDS, UMB inventors have developed a specific peptide composition that is deliverable directly to treat excessive leakage within the lungs due to...
Investigator(s): Alessio Fasano, Blake Paterson, Peter Ward
Keyword(s): Acute Respiratory Syndrome, lung, distress
Docket: AF-2011-011
-
Use of Novel Sulfonamides to Inhibit the Growth of Prostate Cancer Cells and Tumors
Published Thursday, May 29, 2014According to the American Cancer Society, prostate cancer (PCA) is the most common type of cancer found in American men. Currently, the major therapy for PCA in both primary and advanced stages is androgen deprivation. This treatment exerts its effects on target tissue by either blocking androgen synthesis or preventing binding of androgens to...
Investigator(s): Vincent C. O. Njar, Puranik Purushottamachar
Categories: Therapeutics, Small molecules
Keyword(s): prostate cancer, cancer
Docket: VN-2007-026
-
Use of ClyA Hemolysin for Protein Export and Vaccines
Published Thursday, May 29, 2014The UMB inventor has engineered a novel protein export system for efficiently producing recombinant protein from a host cell, constructed with a genetically stabilized expression plasmid incorporating the protein of interest fused to the ClyA hemolysin of Salmonella enterica serovar Typhi. Used in a live-vector vaccine, this system allows the...
Investigator(s): James Galen
Categories: Therapeutics, Vaccines
Docket: JG-2001-022
-
University of Maryland, School of Dentistry OSCE Exam
Published Thursday, May 29, 2014Objective Structures Clinical Exams (OSCEs) are used in the assessment of health sciences professionals (e.g. orthoptics, optometry, medicine, nursing, pharmacy) to test clinical performance and competence in skills such as communication, clinical examination, medical procedures, prescription writing, radiographic...
Investigator(s): Judith A Porter, Doug Brotherton, Shabrez Ahmed, Karen Faraone, Edward G Grace, Cynthia L Idzik-Starr, Andrea M Morgan, Harlan Shiau
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): dental, clinical, exams
Docket: JP-2012-099
-
Broad spectrum antibacterial therapeutic peptides of probiotic origin
Published Thursday, May 29, 2014Bacterial diarrhea still remains the second leading cause of deaths globally, accounting for one fifth of all deaths among children under five. Small bioactive peptides with both Gram-positive and Gram-negative bactericidal activity have been isolated from Lactobacillus GG. These peptides...
Investigator(s): Alessio Fasano, Ruiliang Lu
Categories: Therapeutics, Biologics
Keyword(s): diarrhea, pathogenic bacteria, peptides, probiotic, Lactobacillus, broad spectrum, biologics
Docket: SF-2006-008
-
Total and Phosphorylated IL-1 Receptor-Associated Kinase-1 (IRAK-1) and -4 (IRAK-4) as a Biomarker for Cancer Progression and Chemotherapy Resistance.
Published Thursday, May 29, 2014UMB inventors have identified two proteins active in the TNF receptor-associated factor (TIRAF)/MyD88 pathway, Interleuken-1 Receptor-Associated Kinase (IRAK)-1 and -4, as potential targets for combinatorial therapy reducing chemotherapy resistance in multiple cancer cell lines. IRAK is a...
Investigator(s): Eduardo Davila
Categories: Therapeutics
Keyword(s): chemotherapy, cancer
Docket: ED-2012-072
-
Thermostabilization of DNA Polymerase with Novel Chaperones
Published Thursday, May 29, 2014Dr. Frank Robb has considerable expertise in the study of microbes found in extreme environments and their mechanisms of survival. These astonishing organisms have protein chaperone systems that enable them to survive and even thrive in extreme heat and harsh chemical conditions. An important application for these chaperones is to enhance...
Investigator(s): Frank Robb, Pongpan Laksanalamai
Categories: Research Tools, Antibodies, & Reagents, Engineering, Chemical
Docket: FR-2010-087